Synthesis and Applications of Isotopically-Labelled Compounds

David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree’s catalyst in HIE in 1995.

1. General Introduction
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook