Pulmonary Drug Delivery Systems: Material and Technological Advances (eBook)

This book provides an insight into state-of-art developments in pulmonary drug delivery systems. It comprises several chapters covering a wide range of promising technologies and novel materials explored for developing effective pulmonary drug delivery systems. The initial book chapters elucidate role of thin film freezing, supercritical fluid technology, nano-in-micro particles system, crystal-engineered microstructures and porous particles in pulmonary drug delivery. The subsequent book chapters elaborate on various functional excipients such as chitosan, cyclodextrins, and Vitamin E-TPGS to attain local and systemic therapeutic action. There are book chapters focused on diverse novel carrier systems such as hydrogels, quantum dots, metal-organic framework, and prodrug approach. Additionally, book also contains chapters, exclusively dedicated to biologicals and numerical simulation in pulmonary therapeutics.

The book chapters follow a sequential order, beginning with the pulmonary relevance of technology or polymeric materials, carrier synthesis schemes, current technical state-of-art, along with clinical, industrial, and regulatory aspects. Each chapter contains a future perspective section that will systematically reflect the current state of advances in pulmonary drug delivery. It also offers a practical basis for audience to understand the design and function of the delivery systems for better therapeutic outcomes. The book provides balanced views by considering the investigations from various scientific domains and industrial knowledge.

 Briefly, this book aims to collect, analyse, and bring together the latest developments in pulmonary drug delivery with more focus on materials and technologies. Indeed, this book is a valuable source for readers and researchers who wish to learn more about the advances in pulmonary drug delivery systems.

·Dr. Piyush Pradeep Mehta is currently working as deputy manager in global respiratory R&D at Cipla R&D Centre, Mumbai, India. Dr. Piyush has rich experience in the field of inhaled drug products. He has worked in reputed pharmaceutical companies like Cipla R&D and Zydus Cadila. He has been instrumental in completing a few dry powder inhaler (DPIs) products in India. He has been elected as prestigious Newton-Bhabha Fund, Royal Society Of Chemistry (RSC) Researcher (2019-2020) owing to his contribution to the field of pulmonary drug delivery. He has been selected for On-Demand Presentations on pulmonary drug delivery from The Drug Delivery to the Lungs (DDL 2020), UK because of his contribution to modified throat research. He has also received appreciation for the contribution for Institution's Innovation Council by MHRD's Innovation Cell, Government of India (2018-2019). He was a guest editor for a special issue 'Advances in Orally Inhaled and Nasal Drug Products' in 'Frontiers in Pharmacology' journal. He has filed 4 device patents and published more than 45 articles, book chapters, and scientific communications related to his proficiency in several peer-reviewed journals. He has delivered > 20 presentations at several international summits.

          Dr. Vividha Dhapte-Pawar is working as Associate Professor in department of Pharmaceutics at Poona College of Pharmacy, Pune. Dr. Vividha has worked in novel drug delivery systems, especially nano-formulations, pulmonary medicines, and chemotherapeutics. Dr. Vividha has 02 patent published, 40 international papers and 10 book chapters to her credit. She is a recipient of 6 Gold Medals during her academics as well as at various national competitions along with awards for best oral and poster presentations at national and international conferences. Dr. Vividha is a recipient of AICTE fellowship, Dhirubhai Ambani Scholarship, and Ratan Tata Trust Fellowship. Also, she has received research grants, travel grants from UGC, Bharati Vidyapeeth University, and Pune University. She serves as a consultant for, microbial testing, student start-ups and generic medicines in Hospitals.

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This book provides an insight into state-of-art developments in pulmonary drug delivery systems. It comprises several chapters covering a wide range of promising technologies and novel materials explored for developing effective pulmonary drug delivery systems. The initial book chapters elucidate role of thin film freezing, supercritical fluid technology, nano-in-micro particles system, crystal-engineered microstructures and porous particles in pulmonary drug delivery. The subsequent book chapters elaborate on various functional excipients such as chitosan, cyclodextrins, and Vitamin E-TPGS to attain local and systemic therapeutic action. There are book chapters focused on diverse novel carrier systems such as hydrogels, quantum dots, metal-organic framework, and prodrug approach. Additionally, book also contains chapters, exclusively dedicated to biologicals and numerical simulation in pulmonary therapeutics.The book chapters follow a sequential order, beginning with the pulmonary relevance of technology or polymeric materials, carrier synthesis schemes, current technical state-of-art, along with clinical, industrial, and regulatory aspects. Each chapter contains a future perspective section that will systematically reflect the current state of advances in pulmonary drug delivery. It also offers a practical basis for audience to understand the design and function of the delivery systems for better therapeutic outcomes. The book provides balanced views by considering the investigations from various scientific domains and industrial knowledge. Briefly, this book aims to collect, analyse, and bring together the latest developments in pulmonary drug delivery with more focus on materials and technologies. Indeed, this book is a valuable source for readers and researchers who wish to learn more about the advances in pulmonary drug delivery systems.