In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems

lt;b>Part I: Chemical Analytical and Bioanalytical Techniques in Bioavailability Research: Passive Sampling/Dosing and Bioaccumulation Assessments

1. Equilibrium Sampling of Hydrophobic Organic Contaminants in Sediments

            Gesine Witt, Julia Bachtin, and Sabine Schäfer

2. Passive Sampling of Waterborne Contaminants

            Branislav Vrana, Foppe Smedes, and Klára Hilscherová

3. Using Tenax Extractable Concentrations to Determine the Bioavailable Contaminant Fraction in Sediments

            Amanda D. Harwood and Samuel A. Nutile

4. Quantifying Bioaccumulation in the Aquatic Environment

Part II: Monitoring of Effects In Situ and Bioassays to Assess the Effects of Complex Environmental Samples

5. In Situ Determination of Genotoxic Effects in Fish Erythrocytes Using Comet and Micronucleus Assays

            Paula Suares Rocha, Björn Deutschmann, and Henner Hollert

6. Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios

            Amaia Orbea, Eider Bilbao, and Miren P. Cajaraville

7. In Situ Exposure of Aquatic Invertebrates to Detect the Effects of Point and Non-Point Source-Related Chemical Pollution in Aquatic Ecosystems

8. Whole Sediment Toxicity Bioassay to Determine Bioavailability and Effects of Aquatic Contaminants Using Zebrafish Embryos

            Sabrina Schiwy, Mirna Velki, and Henner Hollert

9. Nematode-Based Effect Assessment in Freshwater Sediments

Part III: Computational Models for Interspecies Comparison and Extrapolation from the Lab to the Field

10. In Vitro-In Vivo Extrapolation to Predict Bioaccumulation and Toxicity of Chemicals in Fish Using Physiologically-Based Toxicokinetic Models

            Julita Stadnicka-Michalak and Kristin Schirmer

11. Cross-Species Extrapolation Using a Simplifed In Vitro Tissue Explant Assay in Fish

            Bryanna Eisner, Jon Doering, Shawn Beitel, and Markus Hecker

12. Extrapolation of Laboratory-Measured Effects to Fish Populations in the Field

            Charles R.E. Hazlerigg