In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems

- Part I: Chemical Analytical and Bioanalytical Techniques in Bioavailability Research: Passive Sampling/Dosing and Bioaccumulation Assessments. - 1. Equilibrium Sampling of Hydrophobic Organic Contaminants in Sediments. - 2. Passive Sampling of Waterborne Contaminants. - 3. Using Tenax Extractable Concentrations to Determine the Bioavailable Contaminant Fraction in Sediments. - 4. Quantifying Bioaccumulation in the Aquatic Environment. - Part II: Monitoring of Effects In Situ and Bioassays to Assess the Effects of Complex Environmental Samples. - 5. In Situ Determination of Genotoxic Effects in Fish Erythrocytes Using Comet and Micronucleus Assays. - 6. Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios. - 7. In Situ Exposure of Aquatic Invertebrates to Detect the Effects of Point and Nonpoint Source-Related Chemical Pollution in Aquatic Ecosystems. - 8. Whole-Sediment Toxicity Bioassay to Determine Bioavailability and Effects of Aquatic Contaminants Using Zebrafish Embryos. - 9. Nematode-Based Effect Assessment in Freshwater Sediments. - Part III: Computational Models for Interspecies Comparison and Extrapolation from the Lab to the Field. - 10. In Vitro-In Vivo Extrapolation to Predict Bioaccumulation and Toxicity of Chemicals in Fish Using Physiologically Based Toxicokinetic Models. - 11. Cross-Species Extrapolation Using a Simplified In Vitro Tissue Explant Assay in Fish. - 12. Extrapolation of Laboratory-Measured Effects to Fish Populations in the Field.