Natural Molecules in Neuroprotection and Neurotoxicity

Dr Oliveira PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a Master’s and a Ph.D. in Biochemistry from the same institution. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models. Dr Oliveira has published numerous articles on peer-reviewed Journals, including Molecular Neurobiology, Chemico-Biological Interactions, Biotechnology Advances, and Oxidative Medicine and Cellular Longevity. He has also edited a book on the effects of plant molecules on the mitochondria Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health and a book on the role of mitochondrial dysfunction in both neurological disturbances and intoxication Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine.

Part I - Overview on Neuroprotection and Neurotoxicity What is neuroprotection? When can a molecule be called neuroprotective? Can natural molecules be used in neurodegenerative diseases? Plant extracts and neuroprotection: challenges and pitfalls Can venoms be used in neuroprotection? The sea as a source of neuroprotective molecules Endoplasmic reticulum in neuroprotection and neurotoxicity Mitochondrial protection in the brain Brain mitochondria intoxication Anti-depressive action of natural molecules Anxiolytic effects caused by natural molecules Anti-tumor effects induced by natural molecules in the brain Plant-derived anti-addiction agents Modulation of neuroinflammation by natural molecules Endogenous molecules associated with neurodegeneration Multi-OMIC Analyses in Neuroprotection "OMIC" Approaches in Neurotoxicology Proteomic and metabolomic approaches in Neurotoxicology Lipidomics in Neurotoxicology Transcriptome in Neurotoxicology Multi-omic Analyses and Astrocyte Computational Models in Neuroprotection and Neurotoxicology "OMIC" Analyses in the Human Microbiota Epigenetic modulations induced by natural molecules Biomarkers utilized in Neurotoxicology

Part II - Neuroprotection mediated by natural molecules Algae-derived molecules Fucoxanthin Marine Algae and Neuroprotection Animal-derived molecules Bee venom Antinociceptive (Phyllomedusa rohdei (Amphibia, Anura) Snake venom Bacteria-derived molecules Botulinum neurotoxins (Clostridium botulinum) Bacteria-derived metabolites in neuroprotection Fungus-derived molecules Endophytic fungus molecules exerting neuroprotection Plant-derived molecules Alkaloids (plants) Andrographolide Anthocyanins Ascorbic acid Baicalein and baicalin Berberine Caffeine Carnosic acid ß-caryophyllene Catechins Chlorogenic acid Citrus flavonoids Cocoa polyphenols Coconut oil components Coumarins (plant-derived) Curcumin Dimethyl fumarate Edible oils Ellagic acid (and urolithin A) Ferulic acid Garlic components (allicin) Gastrodin Genistein Ginger components Ginsenosides Green tea polyphenols Gut bacterial metabolites/Microbiota metabolites Hydroxytyrosol Jasmonates Kahweol Lycopene Mangiferin Monoterpenes Olive oil components Omega-3 polyunsaturated fatty acids Pectins Phloretin and phloridzin Piceatannol Piper components Polyphenols-gut microbiota interplay in neuroprotection Potatoes phytomolecules Protocatechualdehyde/Protocatechuic aldehyde Pterostilbene Quercetin Red wine polyphenols Resveratrol Salvianolic acids Sesamol and sesamin Sulforaphane Tanshinones Thymoquinone Tocopherols and tocotrienols Triterpenes Wogonin Human endogenous molecules Biliverdin and Bilirubin Carnosine (ß-alanyl-L-histidine) Coenzyme Q10 Creatine phosphate Hydrogen sulfide (H2S) Melatonin Nicotinamide (endogenous) Nucleosides

Part III - Neurotoxicity induced by natural molecules Bacteria-derived molecules Type D epsilon toxin (Clostridium perfringens) Cyanobacteria-derived neurotoxins Dinoflagellate-derived neurotoxins Mycotoxins Plant-derived molecules Alkaloids Caffeine Cannabinoids (plant-derived) Lactones Ureases (Canavalia ensiformis) Animal-derived molecules Ant toxins Conotoxin (marine snails) Frog toxins Scorpion toxins Snake venom Spider venom Human endogenous molecules Ammonia Bilirubin Glycotoxicants Endogenous toxicants in Alzheimer’s disease Endogenous toxicants in Huntington’s disease Endogenous toxicants in Parkinson’s disease Hyperhomocysteinemia and ischemic stroke Lipid metabolism-associated endogenous toxicants Neurotoxicity mediated by amino acids and related molecules

Part IV - Natural molecules-associated nanotechnology-related strategies utilized in neuroprotection Neuroprotection through Nanotechnology Antioxidant nanoparticles in neuroprotection Nanomaterials-based approach in stroke Nanotherapy in excitotoxicity Graphene-based nanomaterials in the treatment of neurodegenerative disorders Nanotechnology-based approaches in the treatment of neurodegenerative diseases Nanoparticles and the treatment of depression Nanotechnology-based strategies in the treatment of schizophrenia Anti-tumor effects of natural molecules in the brain: a nanotechnology-based approach Enhancing the bioavailability of vitamins: focus on neuroprotection