Endolysosomal Voltage-Dependent Cation Channels

Part I: Physiological Functions of Endo-lysosomal Cation Channels.- NAADP-Mediated Ca2+ Signalling.- NAADP-Dependent TPC Current.- NAADP-Evoked Ca2+ Signaling: The DUOX2-HN1L/JPT2-Ryanodine Receptor 1 Axis.- TPC Functions in the Immune System.- Lysosomal Ion Channels and Lysosome- 1 Organelle Interactions.- TRPML1 and TFEB, an Intimate Affair.- Lysosomal Potassium Channels.- Part II Structure and Composition of TPC and TRPML Channels.- Structure and Function of Plant and Mammalian TPC Channels.- A Structural Overview of TRPML1 and the TRPML Family.- Endo-Lysosomal Two-Pore Channels and Their Protein Partners.- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels.- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels.- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels.- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.