Mitophagy in Health and Disease

Dr. Lemasters' research is focused on developing and applying new techniques of laser scanning confocal and multiphoton microscopy to characterize the physiology of single living cells, including the assessment of ion homeostasis, mitochondrial function, electrical potentials, oxygen and nitrogen free radical formation, membrane permeability and other biochemical parameters during the pathogenesis of lethal cell injury.

About the editor 1. Overview on mitophagy, mito-dynamics, and mito-biogenesis 2. PINK1-Parkin mitochondrial quality control pathway in Parkinson’s disease 3. Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions 4. Role of AMPK/ULK1 signaling in mitophagy 5. Mitochondrial proteostasis mechanisms (AAA proteases including Lon, proteasomes, CLpP) 6. MitoUPR 7. Mitochondria Derived Vesicles: from Quality Control to Inflammation and Extracellular Vesicles 8. Molecular Regulation of Mitochondrial Turnover by Exercise: Tissue Adaptation through Mitochondrial Biogenesis and Mitophagy 9. Role of mitophagy and mitochondria in aging and cellular senescence 10. Mitophagy in erythropoiesis 11. The dual role of mitophagy in cancer and its targeting for effective anticancer therapy 12. Mitophagy in brain and neurodegenerative disease 13. Anti-aging role of mitophagy 14. Mitophagy in age-associated disease 15. Mitophagy inducers as potential therapeutic agents 16. Transcription factor EB (TFEB) in mitochondrial quality control 17. Cardioprotection through mitophagy 18. Fasting, mitophagy, and aging 19. Mitophagy and Alcoholic and Fatty Liver disease 20. Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis 21. Mitophagy in Yeast 22. Sphingolipid metabolism in the regulation of mitophagy: Implications in cancer therapy, immune cell function and neurodegeneration 23. Formation of mitophagosomes 24. Mitophagy in Hepatic Ischemia/Reperfusion 25. Future developments Author index