Non-Ribosomal Peptide Biosynthesis and Engineering
Springer-Verlag New York Inc.
978-1-0716-3213-0 (ISBN)
Authoritative and cutting-edge, Non-Ribosomal Peptide Biosynthesis and Engineering: Methods and Protocols aims to feature methods that will be beneficial to new researchers, and those wanting to adopt new methodologies into their research.
The Assembly-line Enzymology of Nonribosomal Peptide Biosynthesis.- Structural Studies of Modular Nonribosomal Peptide Synthetases.- Using NMR Titration to Study Protein-Protein Interactions in AcpP Dependent FAS-II.- Chemoproteomic Profiling of Adenylation Domain Functions in Gramicidin S-producing Nonribosomal Peptide Synthetases.- In Vitro Biochemical Characterization of Excised Macrocyclizing Thioesterase Domains from Non-Ribosomal Peptide Synthetases.- Chemo-Enzymatic Synthesis of Non-Ribosomal Macrolactams by a Penicillin-binding Protein-type Thioesterase.- Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4’-Phosphopantetheinyl Transferases to Enable Inhibitor Screening.- Unraveling Structural Information of Multi-Domain Nonribosomal Peptide Synthetases by Using Photo-Crosslinking Analysis with Genetic Code Expansion.- A Chemoenzymatic Approach to Investigate Cytochrome P450 Crosslinking in Glycopeptide Antibiotic Biosynthesis.- Cross-Linking of the Nonribosomal Peptide Synthetase Adenylation Domain with a Carrier Protein Using a Pantetheine-Type Probe.- A Practical Guideline to Engineering Non-Ribosomal Peptide Synthetases.- Probing Substrate-Loaded Carrier Proteins by Nuclear Magnetic Resonance.- Ribosomal Synthesis of Peptides Bearing Noncanonical Backbone Structures via Chemical posttranslational modifications.- Thioester Capture Strategy for the Identification of Nonribosomal Peptide and Polyketide Intermediates.- Chemical Labeling of Protein 4′-Phosphopantetheinylation in Surfactin-Producing Nonribosomal Peptide Synthetases.- Norine: Bioinformatics Methods and Tools for the Characterization of Newly Discovered NonRibosomal Peptides.
Erscheinungsdatum | 18.05.2023 |
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Reihe/Serie | Methods in Molecular Biology |
Zusatzinfo | 54 Illustrations, color; 16 Illustrations, black and white; XI, 321 p. 70 illus., 54 illus. in color. |
Verlagsort | New York, NY |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Naturwissenschaften ► Chemie ► Organische Chemie | |
Schlagworte | Bioinformatics • Biosynthetic enzymes • Non-ribosomal peptide synthetases (NRPSs) • Peptide natural products • Structural and functional diversity |
ISBN-10 | 1-0716-3213-2 / 1071632132 |
ISBN-13 | 978-1-0716-3213-0 / 9781071632130 |
Zustand | Neuware |
Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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