Particle Overload In The Rat Lung And Lung Cancer

Lung overload - the dilemma and opportunities for resolution; from the lab bench to the workplace - implications of toxicology studies on occupational medical practice; epidemiological studies in North American carbon black workers; comparative response to long-term particle exposure among rats, mice and hamsters; significance of particle parameters in the evaluation of exposure-dose-response; relationships of inhaled particles; current information on lung overload in non-rodent mammals; maximum tolerated dose in particulate inhalation studies - a pathologist's point of view; differences between rodents and humans in lung tumor response - lessons from recent studies with carbon black; role of inflammation in the development of rat lung tumors in response to chronic particle exposure; evalution of the carcinogenic risk of biochemically inert insoluble particles by the EPA using rat inhalation data; use of hazard and risk information in risk management decisions - solid particles and fibres under EPA's TSUSAU and EPCRA; lung cancer in rats from prolonged exposure to high concentrates of particles - implications for human risk assessment.