Organic Chemistry of Drug Design and Drug Action

Medicinal Chemistry Folklore. Discovery of New Drugs. Drug Discovery. Design and Development. Drug Discovery. Drug Development. Lead Modification. Receptors. Receptor Structure. Drug-Receptor Interactions. Enzymes (Catalytic Receptors). Enzymes as Catalysts, Mechanisms of Enzyme Catalysis, Co-Enzyme Catalysis. Enzyme Therapy. Enzyme Inhibition and Inactivation. Why Inhibit an Enzyme? Drug Resistance, Drug Synergism (Drug Combination), Reversible Enzyme Inhibitors. Irreversible Enzyme Inhibitors. DNA. Introduction. DNA Structure and Properties. Classes of Drugs that Interact with DNA. Epilogue to Receptor-Interactive Agents. Drug Metabolism. Introduction. Synthesis of Radioactive Compounds. Analytical Methods in Drug Metabolism. Pathways for Drug Deactivation and Elimination. Prodrugs and Drug Delivery Systems. Enzyme Activation of Drugs. Mechanisms of Drug Inactivation. Index.