Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries. Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Preface

I. Alzheimer’s Disease and Dementias

1. Guarana (Paullinia cupana Mart.) and protection against amyloid-beta toxicity: applications to Alzheimer disease and dementias Felix Alexandre Antunes Soares

2. Herbs for Alzheimer’s disease management; Clinical studies: a narrative Narjes Gorji, Zahra Memariani and Reihaneh Moeini

3. Reducing neurodegeneration and oxidative damage in Alzheimer's disease. Role of the Nrf2 pathway activation by natural compounds Francisca Villavicencio-Tejo and R. A. Quintanilla

4. Alzheimer's disease and green coffee bean extract N.N. Younis and R. G. Eissa

5. Callistemon viminalis and protection in Alzheimer's disease Y. Prashar

6. Herbs for Alzheimer's disease management; Preclinical studies: a narrative Narjes Gorji, Reihaneh Moeini and Zahra Memariani

7. Allicin as a nutraceutical: usage in Alzheimer's disease Shivani Chib, Bhaskar Jyoti Dutta, Sudhanshu Mallan, Khadga Raj and Shamsher Singh

II. Amyotrophic Lateral Sclerosis

8. Rutin and applications to Amyotrophic Lateral Sclerosis Uma Maheswari Krishnan

9. Kaempferol and kaempferide and amyotrophic lateral sclerosis E. Srinivasan, G. Chandrasekhar and R. Rajasekaran

III. Brain Injury

10. French maritime pine bark extract and neurological disorders Abdolreza Norouzy

11. Angong Niuhuang Pill could be an Effective Medicinal Agent for Stroke Treatment Jiangang Shen

12. Polyphenols as therapeutic interventions against cerebral ischemic injury Uma Maheswari Krishnan

13. Da Chuanxiong formula and use in traumatic brain injury Zhike Liu, Angela SM Hung, Erik CH KO, Johnny CM Koon and PING-CHUNG LEUNG

IV. Dietary Neurotoxins

14. Coriandrum sativum protection in mercury neurotoxicity Barbarella Macchi, Fábio Oliveira, Moisés Hamoy, Chubert Sena, Edilene Silva, Gabriela Arrifano, Maria Elena Crespo-Lopez and J.L.M. do Nascimento

15. Taurine in symptom amelioration and recovery in lead induced neurotoxicity Lorenz Simon Neuwirth and Bright Emenike

16. Omega-3 Fatty Acid as a protectant in lead induced neurotoxicity Rajendra. Nath

V. Epilepsy

17. Dietary flavonoids and management of epilepsy Damanpreet Singh

18. Magnesium supplemental therapy in epileptogenesis and ictogenesis Jimmy Li and Dènahin Hinnoutondji Toffa

19. Curcumin usage in epilepsy Deepak Sharma and Chandra Prakash

20. Triheptanoin as a nutraceutical and potential use in epilepsy Giovanna Testa, Mario Costa and Marco Mainardi

VI. Headaches and Migraines

21. Dietary supplementation in migraine: a focus on omega-3 fatty acids Fahimeh Martami and Sakineh Shab-bidar

22. Headaches, migraine and herbal medicine Ching-Liang Hsieh

23. Magnesium and migraine Lidia Savi

VII. Multiple Sclerosis

24. Betaine as a neuroprotective therapy for multiple sclerosis Jennifer McDonough and Sarah Sternbach

25. Natural products and their bioactive compounds in Multiple Sclerosis Jasvinder Singh Bhatti

26. The Crocin usage in Multiple sclerosis A. Ranjbar

VIII. Neuroinflammation

27. The Potential Role of Herbal Medicine & Nutraceuticals in Neuroinflammatory Disorders: A Mechanistic Insight via Multi-Signaling Cascades Salman Khan

28. Arbutin as a natural soluble glycosylated phenol and usage in neuroinflammation Maryam Ghasemi-Kasman, Hanie Yavarpour-Bali and Sadaf Abdi

29. Plant-based oils used to treat neuroinflammation Priya Madhavan and Shantini Vijayabalan

30. Clinacanthus nutans leaf’ anti-neuroinflammatory potentials Intan S. Ismail and Amalina Ahmad Azam

31. Nutraceuticals and bioactive components of herbal extract in the treatment and prevention of neurological disorders Chandana Choudhury Barua

32. Effect of tinospora cordifolia on neuroinflammation Vipin V. Dhote, Mohan Raja, Aman B. Upaganlawar, Vaishali Kilor, Ashish Singhai and Avinash Singh Mandloi

33. Neuroprotective potential of quercetin as a nutraceutical targeting fused neuroinflammation in neurological disease Ayansh Kaushik, Kanupriya Chauhan and Shamsher Singh

IX. Parkinson’s Disease

34. Pre and Probiotics and Parkinson’s Disease Reza Amani and Sanaz Mehrabani

35. Omega 3 polyunsaturated fatty acids and its use in Parkinson disease Abril Ramírez-Higuera, Carolina Peña-Montes, Alejandra Barroso-Hernández, Oscar López-Franco and Rosa María Oliart-Ros

36. The flavone chrysin and usage in Parkinson's Disease Ankita Murmu, Alagudurai Krishnamoorthy and Murugan Sevanan

37. Blackberry (Morus nigra) and usage in Parkinson's Disease Yasir Hasan Siddique, Gulshan Ara and Falaq Naz

X. Peripheral Neuropathy

38. Use of coumarin osthole in peripheral neuropathy Rajbir Bhatti and Lovedeep Singh

39. Therapeutic Benefits of Phenolic Acids in Peripheral Neuropathy Shubhangi Hemraj Pawar

40. Resveratrol as a potential therapeutic molecule against neuropathy- a new narrative Irshad Ahmad, Rukkumani Rajagopalan, ABHIJIT DEY and Muddasarul Hoda

41. Effect of kaempferol and use in peripheral neuropathy Prerna Sharma, Aishwarya Gangwar, Nidhi Rani and Randhir Dahiya

42. Cleistocalyx nervosum var. paniala fruit on neuropathy Wathita Phachonpai

XI. Prenatal Effects and Neurodevelopment

43. Nutritional supplementation for the prevention and treatment of neonatal brain injury: Breast milk and beyond Myrna Brandt, Cora Nijboer, Ruurd van Elburg, Manon J. N. L. Benders and Caroline Gillis Marleen de Theije

44. Maternal naringenin supplementation during pregnancy disrupts the redox status in the developing rats’ brain Bernardo Gindri dos Santos, Pauline Maciel August and Cristiane Matte

45. Tryptophan as a supplement in cerebral palsy Diego Lacerda, Diego Visco and A. E. Toscano

46. Centella asiatica and protection in neurodevelopment G. Bolumbu

XII. Stroke

47. Genistein and use in neuroprotective agent in stroke Derek A. Schreihofer

48. Leucine-enriched amino acid supplement and use in stroke Takashi IKEDA and Nobuo Morotomi

49. Arginine and neuroprotection: a focus on stroke Yasutoshi Koga Sr.

50. Isoflavones as neutraceuticals in stroke: therapeutic targets and signalling pathways M. Ram Pravin Kumar, C. Vijayalakshmi and M. Ramanathan

51. Trigonelline and uses in stroke Pallab Bhattacharya

XIII. Resources

52. Research and Resources Rajkumar Rajendram