Computational Models in Biomedical Engineering (eBook)

Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. - Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use - Enables the modeling of complex physical field problems and the mechanics of biological systems - Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung - Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics

Dr. Milos Kojic is one of the leading scientists in the computational mechanics and finite element method and its application in engineering and biomedicine. He is currently Full Member and Professor of Nanomedicine, Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA, as well as the Director of the Bioengineering R&D Center, Kragujevac, Serbia. In his long professional carrier, Dr. Kojic has been Professor of Mechanics at University of Kragujevac, Serbia (retired), Visiting Scholar of MIT; Research and Development Engineer of ADINA R&D, Boston; Senior Research Scientist, Harvard School of Public Health; and Member of the Serbian Academy of Science and Arts, from 2009. Dr. Kojic's research is primarily concerning the finite element method, implementation in engineering and biomedicine; and software development. He has formulated and implemented a number of original concepts and solutions, among which is the Governing Parameter Method for inelastic analysis of solids and structures, and recently the smeared finite element models for field problems and mechanics, also known as the Kojic Transport Model (KTM). He initiated and has been PI of the FE software package PAK for solids and fluids, field and coupled problems, and biomechanics. The PAK software has been developing over decades with participation of several generations; today, it is the basic tool for applications in industry and in research within various domestic and international grants. Dr. Kojic is the lead author of over 10 textbooks in Serbian and two books by world leading publishers: Inelastic Analysis of Solids and Structures, from Springer, and Computer Modeling in Bioengineering, from J. Wiley and Sons.

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Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. - Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use- Enables the modeling of complex physical field problems and the mechanics of biological systems- Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung- Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics