Epigenetics in Health and Disease

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University. Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Preface

Indra Mani and Vijai Singh

1. Insight into epigenetics and human diseases

Ankita Saini, Adya Varshney, Ashok Saini and Indra Mani

2. State-of-the-art techniques to study epigenetics

Ashok Saini, Yashaswi Rawat, Kritika Jain and Indra Mani

3. Mechanisms of DNA methylation and histone modifications

Santoshi Acharjee, Shraddha Chauhan, Rajshree Pal and Raghuvir Singh Tomar

4. Epigenetics, genomics imprinting and non-coding RNAs

Gautham Manoj, Anjali Krishna, Anandhu Presannan, Nidheesh M, Renuka Suravajhala and Prashanth Suravajhala

5. Epigenetics in cardiovascular health and disease

Nicholas W.S. Chew, Shaun Loong and Roger Foo

6. Histone modifications in fat metabolism and obesity

Dinh-Toi Chu, Yen-Vy Nguyen Thi and Nicholas W.S. Chew

7. Role of DNA methylation in diabetes and obesity

Dinh-Toi Chu, Nhat-Le Bui, Hue Vu Thi and Yen Vy Nguyen Thi

8. Epigenetic regulation of aging

Sarita Mishra, Mahima Raval, Akanksha Singh Kachhawaha, Budhi Sagar Tiwari and Anand Krishna Tiwari

9. Epigenetics in fetal alcohol spectrum disorder

Balapal S. Basavarajappa

10. Epigenetic regulation of pluripotency inducer genes NANOG and SOX2 in human prostate cancer

Niharika, Ankan Roy, Jagdish Mishra, Subhajit Chakraborty, Suraj Pratap Singh and Samir Kumar Patra

11. Mechanistic aspects of reversible methylation modifications of arginine and lysine of nuclear histones and their roles in human colon cancer

Ankan Roy, Niharika, Subhajit Chakraborty, Jagdish Mishra, Suraj Pratap Singh and Samir Kumar Patra