Immunological Tolerance

Mechanisms of peripheral T-cell tolerance; molecular and genetic mechanisms for maintaining self-tolerance in B-cells; mechanisms and consequences of partial T-cell activation; tolerance and determinant hierarchy; molecular recognition of the T-lymphocyte responses in the healthy and diseased immune system; co-stimulatory and inhibitory aspects of T-cell activation; antigen-specific CD4+ T-cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect; antigen-specific immune suppression - tolerance or what?; tolerance induction to transplanted tissues using monoclonal antibodies (What are the mechanisms?); two-step induction of autoimmunity involving reversal of tolerance and conditioning of the target organ; cross-presentation of self antigen to CD8+ T-cells - the balance between tolerance and autoimmunity; tolerance induction in mature T-lymphocytes; T-lymphocyte mediated control of autoimmunity.