The NMDA Receptor -

The NMDA Receptor

Buch | Softcover
518 Seiten
1995 | 2nd Revised edition
Oxford University Press (Verlag)
978-0-19-262502-1 (ISBN)
259,95 inkl. MwSt
Updates coverage on the NMDA receptor - a protein in the brain involved in the electrical and chemical processes which may underlie learning and memory. These receptors are also thought to contribute to stroke-induced brain damage and Alzheimer's disease.
This book comprises an up-to-date and comprehensive coverage of the NMDA receptor. The NMDA receptor is an important protein in the brain which is involved in physiological processes such as synaptic transmission and synaptic plasticity which may underlie learning and memory. Pathological changes involving the NMDA receptors probably contribute to the development of epilepsy, acute neuronal damage such as that resulting from stroke and chronic neuropathologies such as Alzheimer's disease. There is considerable interest in the development of pharmacological agents active at NMDA receptors as new therapeutic agents.

Each chapter in this book has been prepared by a leading expert in the field and has been fully updated to cover recent developments in the molecular biology and the molecular pharmacology of the NMDA receptor. This is the only book of its kind in the world.

2) Agonists and competitive antagonists: structure, activity and molecular modelling studies ; 3) Non-competitive antagonists of N-methyl-D-aspartate ; 4) Molecular pharmacology of NMDA receptors ; 5) Molecular biology of NMDA receptors ; 6) Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes ; 7) The NMDA receptor, its channel, and its modulation by glycine ; 8) The time-course of NMDA receptor-mediated synaptic currents ; 9) Activation of NMDA receptors ; 10) NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system ; 11) The importance of NMDA receptors in the processing of spinal primary afferent input patterns ; 12 ) The role of NMDA receptors in synaptic integration and the organization of motor patterns ; 13) NMDA receptors and long-term potentiation in the hippocampus ; 14) NMDA receptors and developmental plasticity in visual neocortex ; 15) The role of NMDA receptors in learning and memory ; 16) Clinical implications of NMDA receptors ; 17) The NMDA receptor in epilepsy ; 18) NMDA receptors, neuronal development, and neurodegeneration ; 19) Competitive NMDA antagonists as drugs ; 20) Non-competitive NMDA antagonists as drugs ; 1) The NMDA receptor concept: origins and development

Erscheint lt. Verlag 9.2.1995
Zusatzinfo 1 colour illustration, halftones, numerous line figures, tables
Verlagsort Oxford
Sprache englisch
Maße 155 x 234 mm
Gewicht 887 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 1. Studienabschnitt (Vorklinik) Anatomie / Neuroanatomie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 0-19-262502-0 / 0192625020
ISBN-13 978-0-19-262502-1 / 9780192625021
Zustand Neuware
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