Handbook of Brain Tumor Chemotherapy

Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

I. Pharmacology and Clinical Applications.
1. Overview of Brain Tumor Epidemiology and Histopathology.
2. Clinical Pharmacology of Brain Tumor Chemotherapy.
3. Chemotherapy and Anti-Epileptic Drug Interactions.
4. Brain Tumor Models for Cancer Therapy.
5. Microarray Analysis and Proteomic Approaches to Drug Development.
6. Chemotherapy Resistance.
7. Clinical Trial Design and Implementation.

II. Molecular Biology and Basic Science.
8. Molecular Genetics of Brain Tumors - An Overview
9. Regulation of the Cell Cycle and Interventional Developmental Therapeutics.
10. Apoptosis Pathways and Chemotherapy.
11. Growth Factor Signaling Pathways and Receptor Tyrosine Kinase Inhibitors.
12. Ras Signaling Pathways and Farnesyl Transferase Inhibitors.
13. PI3-Kinase, PKB/Akt, mTOR, and Internal Signaling Pathways.
14. Tumor Invasiveness and Anti-invasion Strategies.
15. Mechanisms of Angiogenesis in Brain Tumors and their Translation into Therapeutic Anti-tumor Strategies.
16. Biology of the Blood-Brain and Blood-Brain Tumor Barriers.

III. Innovative Approaches to Chemotherapy Delivery.
17. Intra-Arterial Chemotherapy.
18. Blood-Brain Barrier Disruption Chemotherapy.
19. Interstitial Chemotherapy and Polymer-Drug Delivery.
20. Intratumoral Administration and Convection-Enhanced Delivery.
21. Marrow Ablative Chemotherapy with Hematopoietic Stem Cell Rescue.
22. CSF Dissemination of Primary Brain Tumors.
23. Chemotherapy-Activating Gene Therapy.

IV. Chemotherapy of Specific Tumor Types.
24. Chemotherapy of High-Grade Astrocytomas.
25. Chemotherapy of Low-Grade Astrocytomas.
26. Chemotherapy of Oligodendrogliomas.
27. Chemotherapy of Oligoastrocytomas.
28. Chemotherapy of Primary Central Nervous System Lymphomas.
29. Chemotherapy of Medulloblastoma.
30. Chemotherapy of Ependymoma.
31. Chemotherapy of Glioneuronal Tumors.
32. Chemotherapy of Pineal Parenchymal Tumors.
33. Current Therapeutic Management Strategies for Primary Intracranial Germ Cell Tumors.
34. Chemotherapy of Menigiomas.
35. Chemotherapy for Brain Metasteses.
36. The Role of Chemotherapy in Pediatric Gliomas.