Molecular Mechanisms Controlling Transmembrane Transport

Reinhard Krämer is chair in Biochemistry at Cologne University, Germany. After studying Biochemistry at the Universities of Tübingen and Munich, he obtained his Ph.D. from LMU Munich. He then spent 10 years at the Research Center Jülich (Institute of Biotechnology) and the University of Düsseldorf as an Associate Professor for Biochemistry before taking up his present position at Cologne University. During his scientific career, R. Krämer has focused on different aspects of membrane transport proteins, both in mitochondria and in prokaryotes, as well as on stress response in bacteria, in particular osmotic stress.

Role of Transporter-like Sensors in Glucose and Amino Acid Signalling in Yeast.- Transcriptional Regulation of Intestinal Nutrient Transporters.- Transport-Dependent Gene Regulation by Sequestration of Transcriptional Regulators.- Regulation of Carrier-mediated Sugar Transport by Transporter Quaternary Structure.- Regulation and Function of Ammonium Carriers in Bacteria, Fungi, and Plants.- Osmoregulation and Osmosensing by Uptake Carriers for Compatible Solutes in Bacteria.- The Bacterial Phosphotransferase System: a Perfect Link of Sugar Transport and Signal Transduction.- Ancillary Proteins in Membrane Targeting of Transporters.- Regulation of Transporter Trafficking by the Lipid Environment.- Trafficking of Vesicular Transporters to Secretory Vesicles.- Regulated Transport of the Glucose Transporter GLUT4.- Molecules in Motion: Multiple Mechanisms that Regulate the GABA Transporter GAT1.- Generation of Transporter Isoforms by Alternative Splicing.- Membrane Trafficking of Yeast Transporters: Mechanisms and Physiological Control of Downregulation.