Regenerative Therapies in Ischemic Stroke Recovery (eBook)

This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.

Dr. Syed Shadab Raza is an Associate Professor, and head of the Department of Stem Cell and Regenerative Medicine, Era's Lucknow Medical College and Hospital, India. He is also serving as an Assistant Dean of the Faculty of Basic Medical Science, Era University and is a Visiting Scientist at the American University of Barbados, Latin America. His research focuses on translational (stem cell and nanotechnology) therapy for stroke recovery. Specifically, he is interested in exploring the potential of stem cell and nanoparticle therapy to treat ischemic stroke. He has received various prestigious awards, notably, the International Brain Research Organization Fellowship, Japan Neuroscience Society Award, Indian Academy of Biomedical Sciences Neuroscience Award, InStem Fellowship, IBRO-ABRC Fellowship, and Council for Scientific Industrial and Research Fellowship. In the year 2020, Dr. Raza has been elected as a Fellow of the Royal Society of Biology.

He is a member of the editorial board and reviewer for several prestigious journals of international repute, such as Frontiers in Neuroscience, Frontiers in Pharmacology, Stem Cell Research and Therapy, World Journal of Stem Cells, Recent Patents on Drug Delivery and Formulation. He has published more than 41 research articles in peer-reviewed international journals and co-authored several book chapters. He is a member of several national and international scientific societies, such as the National Academy of Sciences India, Indian Society of Regenerative Science, Indian Stem Cell Study Group Association, Japan Neuroscience Society, Indian Science Congress Association, Indian Society of Cell Biology, Society for Neurochemistry India, and the Indian Academy of Neuroscience.

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This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.