Role of MicroRNAs in Cancers (eBook)

This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.

Dr. Prasad DKV is an Associate Professor in Department of Biochemistry and In-charge Central Research Laboratory, NRI Institute of Medical Sciences at Visakhapatnam, Andhra Pradesh. Dr.Prasad obtained his medical degree from Nagarjuna University, Andhra Pradesh., M.Sc. (Psychology) from Madras University., M.Sc. (Medical Biochemistry) and Ph.D. (Medical Biochemistry) from Dr. N.T.R. University of Health Sciences, Vijayawada, Andhra Pradesh. He has more than 25 years of teaching experience in Biochemistry and also mentored medical graduate and Post-graduate medical biochemistry students to his credit. His research focused on genetics of idiopathic generalized epilepsy (IGE) and its association with oxidative stress and antiepileptic drug therapy. He successfully published his work in national and internationally reputed journals and authored or co-authored few book chapters.  He also presented abstracts at various national and international conferences. Dr Prasad tries to lead by example, promoting honesty, integrity, laboratory safety and a healthy work-life balance. In the laboratory, he encourages each student to take ownership of their project, providing scaffolding, advice and troubleshooting when necessary but ultimately letting each person design their own path. He provides opportunities to practice key skills including oral presentations, literature analysis and scientific writing and encourage participation in conferences, internship experiences and travel to work with collaborators around the globe. Dr.Prasad has completed the clinical biochemistry degree MIBCB (Member of Indian Board of Clinical Biochemistry), which is empanelled by Quality Council of India (QCI). He is a member of many international scientific societies and organizations. He is a member secretary for Institutional Ethics Committee, NRI Institute of Medical Sciences, Visakhapatnam. He is a reviewer of several international journals and serves as editorial board member for well reputed international and national journals.

Dr. Pinninti Santosh Sushma is a postdoctoral fellow at University of Alabama, Birmingham. Previously, she has completed her Ph.D. from the National Institute of Nutrition. Her work was focused on understanding the role of microRNA in different cancers specifically on the mechanisms of microRNAs targeting tumor suppressor genes and DNA methylation patterns. She has published several research articles in national and international journals of high repute.

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This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.