Handbook of Experimental Pharmacology / Neurotrophic Factors

This volume provides the first comprehensive overview of a novel field of neuropharmacology. Neurotrophic factors are currently in clinical trials and there is a broad research effort which aims at alternative administration strategies and at replacing them with small molecule mimetics. The field represents a unique and novel approach to the treatment of neurodegenerative diseases.
TOC: Biological Roles of Neurotrophins.- Molecular Anatomy of Neurotrophic Factors.- Neurotrophic Treatment of Peripheral Sensory Neuropathies.- Neurotrophic Factors and Amyotrophic Lateral Sclerosis.- Pharmacology of Insulin-like Growth Factors (IGF-I).- Neurotrophic Factors in Peripheral Nerve Injury and Regeneration.- Nerve Growth Factor Treatment for Alzheinmer's Disease, the Experience of the First Attempt of Intracerebral Neurotrophic Factor Therapy.- Neurotrophic Roles of GDNF and Related Factors.- Role of Neurotrophic Factors in Cerebral Ischemia in Stroke and Acute Nervous System Injury.- Strategies for Administering Neurotrophic Factors to the Central Nervous System.- Neurotropic Factor Mimetics.