Neurotransmitters and Drugs

1 Neurotransmission: Sites at which drugs modify neurotransmission.- 1.1 The neurone.- 1.2 Axonal transport.- 1.3 Neuronal cell membranes.- 1.4 Precursors.- 1.5 Synthesis.- 1.6 Storage.- 1.7 Organelles and enzymes.- 1.8 Release.- 1.9 Receptors.- 1.10 Inactivation.- 1.11 Neurotransmitters or neuromodulators.- 1.12 Neurotransmitters in the nervous system.- 1.13 Neurotransmitters and drugs.- Further reading.- 2 Acetylcholine.- 2.1 Synthesis.- 2.2 Storage.- 2.3 Release.- 2.4 Cholinergic receptors.- 2.5 Inactivation of acetylcholine.- 2.6 Therapeutic applications and consequences of drugs acting at cholinergic synapses.- Further reading.- 3 Noradrenaline.- 3.1 Synthesis.- 3.2 Storage.- 3.3 Release.- 3.4 Adrenoreceptors.- 3.5 Inactivation of noradrenaline.- 3.6 Therapeutic applications and consequences of drugs acting at noradrenergic synapses.- Further reading.- 4 Dopamine.- 4.1 Synthesis.- 4.2 Storage.- 4.3 Release.- 4.4 Dopamine systems.- 4.5 Inactivation of dopamine.- 4.6 Therapeutic applications and consequences of drugs acting at dopaminergic synapses.- Further reading.- 5 5-Hydroxytryptamine.- 5.1 Synthesis.- 5.2 Storage.- 5.3 Release.- 5.4 5-HT receptors.- 5.5 Inactivation of 5-HT.- 5.6 Therapeutic applications and consequences of drugs acting at 5-HT synapses.- Further reading.- 6 Histamine.- 6.1 Synthesis.- 6.2 Storage.- 6.3 Release.- 6.4 Histamine receptors.- 6.5 Inactivation of histamine.- 6.6 Therapeutic applications and consequences of drug action on histamine systems.- Further reading.- 7 Inhibitory amino acids: GABA, glycine and taurine.- 7.1 Amino acids as neurotransmitters.- 7.2 ?-aminobutyric acid.- 7.3 Glycine.- 7.4 Taurine.- Further reading.- 8 Excitory amino acids: L-glutamic acid and L-aspartic acid.- 8.1 Synthesis.- 8.2 Storage.- 8.3 Release.- 8.4Excitatory amino acid receptors in the CNS.- 8.5 Inactivation of released excitory amino acids.- 8.6 Functional roles of cerebral excitory amino acid neurotransmitters.- Further reading.- 9 Peptides and neuronal function.- 9.1 Peptides as neurotransmitters and hormones.- 9.2 Synthesis, storage, transport, release and inactivation of neuropeptides.- 9.3 Co-existence and co-transmission of peptides with classical neurotransmitters.- 9.4 Opioid peptides.- 9.5 Substance P (the tachykinins).- 9.6 Cholecystokinin (CCK).- 9.7 Vasoactive intestinal polypeptide.- 9.8 Neurotensin.- 9.9 Somatostatin.- 9.10 Bombesin.- Further reading.

From reviews of previous editions:; The structural organisation of the book is excellent. Trends in Neurosciences; The authors have produced a well thought out book, and as an adjunct to more detailed texts, I would recommend this book to second year pharmacology, and medical students. Biochemical Society Transactions; During its brief existence, Neurotransmitters and Drugs has become a standard undergraduate text in pharmacology and is strongly to be recommended for the relevance of its material and clarity of its presentation. Journal of Clinical and Hospital Pharmacy; A good introduction to the pharmacology of neurotransmission, a subject which is yearly increasing in importance. The prose is economic, the style didactic and the result highly effective. British Journal of Psychiatry