Biomedical Applications of Inorganic Photochemistry

Peter C. Ford is at the Department of Chemistry and Biochemistry, University of California Santa Barbara, CA, USA. Rudi van Eldik was born in Amsterdam (The Netherlands) in 1945 and grew up in Johannesburg (South Africa). He received his chemistry education and DSc degree at the former Potchefstroom University (SA), followed by post-doctoral work at the State University of New York at Buffalo (USA) and the University of Frankfurt (Germany). After completing his Habilitation in Physical Chemistry at the University of Frankfurt in 1982, he was appointed as Professor of Inorganic Chemistry at the Private University of Witten/Herdecke in 1987. In 1994 he became Professor of Inorganic and Analytical Chemistry at the University of Erlangen-Nürnberg, from where he retired in 2010. At present he is Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland, and Visiting Professor of Inorganic Chemistry at the N. Copernicus University in Torun, Poland. His research interests cover the elucidation of inorganic and bioinorganic reaction mechanisms, with special emphasis on the application of high pressure thermodynamic and kinetic techniques. In recent years his research team also focused on the application of low-temperature rapid-scan techniques to identify and study reactive intermediates in catalytic cycles, and on mechanistic studies in ionic liquids. He is Editor of the series Advances in Inorganic Chemistry since 2003. He serves on the Editorial Boards of several chemistry journals. He is the author of over 880 research papers and review articles in international journals and supervised 80 PhD students. He has received honorary doctoral degrees from the former Potchefstroom University, SA (1997), Kragujevac University, Serbia (2006), Jagiellonian University, Krakow, Poland (2010), University of Pretoria, SA (2010), and Ivanovo State University of Chemistry and Technology, Russia (2012). He has developed a promotion activity for chemistry and related experimental sciences in the form of chemistry edutainment presentations during the period 1995-2010. In 2009 he was awarded the Federal Cross of Merit (‘Bundesverdienstkreuz’) by the Federal President of Germany, and the Inorganic Mechanisms Award by the Royal Society of Chemistry (London). His hobbies include music, hiking, jogging, cycling and motor-biking. He is the father of two and grandfather of four children.

Preface Peter C. Ford and Rudi van Eldik 1. Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications Justin J. Wilson 2. Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapy Lawrence Cho-Cheung Lee and Kenneth Kam-Wing Lo 3. Advances in the design of photoactivated platinum anticancer complexes Huayun Shi and Peter J. Sadler 4. Adventures in the photo-uncaging of small molecule bioregulators Peter C. Ford 5. Inorganic nanoparticles engineered for light-triggered unconventional therapies Aurore Fraix and Salvatore Sortino 6. Photoactive manganese carbonyl complexes with fac-{Mn(CO)3} moiety: Design, application, and potential as prodrugs in CO therapy Indranil Chakraborty and Pradip K. Mascharak 7. Mechanistic insight into photoactivation of small inorganic molecules from the biomedical applications perspectives A. Kyziol, L. Orzel, I. Gurgul, O. Mazuryk, P. Labuz and G. Stochel 8. Ruthenium complexes for photoactivated dual activity: Drug delivery and singlet oxygen generation Sean J. Steinke, Jeremy J. Kodanko and Claudia Turro 9. Photochemical biosignaling with ruthenium complexes Oscar Filevich and Roberto Etchenique 10. Ruthenium phthalocyanines in nitric oxide modulation and singlet oxygen release: selectivity and cytotoxic effect on cancer cell lines Renata Galvão de Lima, Rafaella Rebecchi Rios, Antonio Eduardo da Hora Machado and Roberto Santana da Silva 11. Photoactive Organometallics as Antimicrobial Agents Ashwene Rajagopal, Jack Biddulph, Leila Tabrizi, Deirdre Fitzgerald-Hughes and Mary T. Pryce 12. Mitochondria-Targeting Transition Metal Complexes Ryan J. Morris and Massimiliano Massi