Chemical Protein Synthesis

Sulfated Glycoprotein Synthesis.- Total Chemical Synthesis of a SARS-CoV-2 Miniprotein Inhibitor LCB1.- Serine/Threonine Ligation and Cysteine/Penicillamine Ligation.- Continuous-flow synthesis of N-Methylated Peptides via Generation of an Acyl N-Methylimidazolium Cation.- Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction.- Ynamide-Mediated Synthetic Approach to Thioamide Substituted Peptides.- Improved Handling of Peptide Segments Using Side Chain-Based “Helping Hand” Solubilizing Tools.- Helical Stabilization of Peptide Macrocycles by Stapled Architectures.- General solution to the preparation of ꞵ-thiolated/Selenolated Amino Acids Via Visible Light Catalyzed Asymmetric Giese reaction.- Side-chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters.- Preparation of Site-Specific Succinylated Histone Mimics to Investigate ItsImpact On Nucleosome Dynamics.- Protein Synthesis Via Activated Cysteine-Directed Protein Ligation.- Sulfonium Tethered Peptide.- PAL-mediated Ligation for Protein and Cell-Surface Modification.- Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation.- A Selenium-Based Cysteine Surrogate for Protein Chemical Synthesis.- Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins.