Myelodysplastic Syndrome and Cytokines

Effects of cytokines on hematopoietic progenitor cells and hematopoiesis. The targets and biological effects of G- and GM-CSF. The role of GM-CSF in spontaneous colony-formation of chronic myelomonocytic leukemia cells. The regulation of colony stimulating factor gene expression. Molecular analysis of the SCL and GM-CSF receptor genes in leukemia. Differentiation pathways of clone-sorted CD34-positive cells. Is LD78 a human counterpart of MIP-1# (stem cell inhibitor) ?. A novel acute lymphoblastic leukemia cell line with negative proliferative effect by interleukin 3. Establishment of a IL-6-dependent plasma cell leukemia cell line. The role of megakaryoblasts derived transforming growth factor-beta in myelofibrosis. Colony stimulating factors: Regulation of production. Molecular mechanism of cross-inhibition of GM-CSF binding to KG-1 cells by IL-3. Suppression of clonogenicity of human leukemic cells by recombinant hemopoietic factors. Mechanism of synergy among hrG-GSF, hrGM-CSF and hrIL-3. Effect of cytokines on murine thrombocytopoiesis: A potent thrombopoietic activity of interleukin-6. Effects of in vivo administration of cytokine on the immune system and the hematopoiesis in murine allogeneic bone marrow chimeras. Double negative (CD4-, CD8-) TCRalphabeta+ adult T cell leukemic cells proliferated vigorously in the presence of IL-2 or IL-4. The cytotoxic effect of tumor necrosis factor against leukemic cells. Granulopoiesis in a MDS patient with monosomy 7: Probable deprivation of granulocytes not from G-CSF but I1-3 and GM-CSF dependent progenitors. Granulocyte colony-stimulating factor cooperated with retinoic acid on the induction of differentiation of acute promyelocytic leukemia cells in vitro. Effects of G-CSF and GM-CSF on cytotoxic activity of cytosine arabinoside and daunorubicin in acute myeloid leukemia. The expression of human granulocyte colony-stimulating factor receptor and differentiation of acute myeloid leukemic cells. Possible pathophysiological roles of G-CSF in myelodysplastic syndromes (MDS): A case report. Serum granulocyte colony-stimulating factor levels in hematological malignancies. Synergistic effects of CSFs on the proliferation and differentiation of leukemia progenitor cells. Cytokine gene expression in acute leukemia. The inhibitory effect of interleukin 4 on the spontaneous growth of chronic myelomonocytic leukemia cells. Effect of recombinant cytokines and a protein produced by MC-1 cell line on murine megakaryocytopoiesis. Combined administration of recombinant human granulocyte-macrophage colony stimulating factor and recombinant human erythropoietin in a patient with refractory anemia. Effects of recombinant human interleukin 1 beta, recombinant human interleukin 2, and recombinant murine tumor necrosis factor alpha on the reconstitution of hematopoiesis and immune functions in lethally irradiated mice transplanted with synergeneic bone marrow cells.