Anti-Aging Pharmacology

Vitaly K. Koltover D. Sci. (Biology - Biological Physics), Ph. D. (Physics & Mathematics - Chemical Physics) works as the chief researcher in Department of Kinetics of Chemical and Biological Processes, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia (http://www.icp.ac.ru). Graduated Taras Shevchenko University in Kiev, Ukraine, (former SU), Holds PhD in Physics and Mathematics (Chemical Physics), and SciD in Biology (Biological Physics). As invited scientist, visited Austria (Institute of Pharmacology and Toxicology, Vienna); Germany (Max-Planck Institute for Demographic Research, Rostock and Albert-Ludwig University, Freiburg); India (Indian Institute of Technology, Chennai and Bhabha Atomic Center, Mumbai); Israel (Shamoon College of Engineering, Beer Sheva), USA (National Lawrence Laboratory in Berkeley, University of Pennsylvania in Philadelphia, Northwestern University in Evanston). Presented plenary lectures and oral presentations at the scientific meetings in Russia, Austria, Canada, China, France, Greece, India, Italy, Israel, Japan, Ukraine, and USA. Published more than 300 scientific papers, including books, conference proceedings and papers in the representative journals. Main research interests, at the present time, are reliability (robustness) and aging of biological systems, free radicals and antioxidants, magnetic isotopes and nuclear spin catalysis in living systems.

SECTION I. Conceptual and Methodological Backgrounds 1. Can Aging be Cured as a Disease? 2. Geroscience Conceipt 3. Mechanistic Pathways of Aging 4. Biomarkers of Aging Rate 5. Artificial Intelligence-Based Approach in Anti-Aging Pharmacology 6. Big Data Approach 7. OMICs Approaches

SECTION II. Basic Classes of Anti-Aging Drugs 8. Antioxidant Paradox 9. Melatonin 10. Calorie Restriction Mimetics 11. Metformin 12. Rapamycin and rapalogs 13. Nonsteroidal Anti-Inflammatory Drugs 14. Statins 15. Senolytics 16. Epigenetic Drugs 17. Sirtuin Activating Compounds 18. Autophagy Inducers 19. Mitophagy Modulators 20. Telomerase Activators

SECTION III. Phytochemicals 21. Resveratrol 22. Curcumin 23. Quercetin 24. Genistein 25. Epigallocatechin Gallate 26. Berberine 27. Nanodelivery of phytobioactive compounds: a promise in anti-aging medicine

SECTION IV. Outcomes and Concluding Thoughts 28. Ethical perspectives on advances in biogerontology 29. Implications for Public Health Policy 30. The Business of Anti-Aging Science