Applications of CRISPR-Cas9 in Translational Research

Dr. Jawed Iqbal is presently working as a Ramalingaswami Fellow and Assistant Professor in the Multidisciplinary Centre for Advanced Research and Studies (MCARS), Jamia Millia Islamia. Previously, he has done his Ph.D. from the J. N. Medical College, A.M.U. Later on, he carried postdoctoral research from C.M.S., Illinois, U.S.A. He has a patent on the Portable Detection System for sensitive estimation of analytes. His research interest is on understanding the viruses and host innate responses and the applications of CRISPR/Cas 9 in the healthcare system. He has recently developed a mobile phone integrated point of care diagnostic device for detecting COVID-19, named CASSPIT (Cas13 Assisted Saliva-based & Smartphone Integrated Testing), and is currently under transfer to the diagnostic company for manufacturing at the mass level. He has published more than 50 research articles in various peer-reviewed international journals of repute.

Chapter 1: Evolution of CRISPR/Cas 9 as gene editing tool-Introduction chapter a) Brief History., b) Types of CRISPR/Cas system, c) Optimized gene knockout using CRISPR/Cas, d) CRISPR/Cas- based technologies.- Chapter 2: CRISPR/Cas 9 in prokaryotes: beyond adaptive immunity.- Chapter 3: Potential of CRISPR/Cas 9 in environmental and agriculture sciences.- Chapter 4: Clinical applications of CRISPR/Cas9 gene editing.- Chapter 5: CRISPR/Cas9-based strategies against infectious diseases.- Chapter 6: Diagnostics Application of CRISPR/Cas 9.- Chapter 7: CRISPR/Cas9 in biomedical engineering.- Chapter 8: CRISP/Cas: ethical and social issues.- Chapter 9: CRISPR/Cas: Challenges and future opportunities.