Frontotemporal Dementias

lt;p>Bernardino Ghetti is Doctor of Medicine and Specialized in Mental and Nervous Diseases from the University of Pisa, Italy. At the Albert Einstein College of Medicine, New York, he completed Research Fellowships of Italian National Research Council and North Atlantic Treaty Organization and then Residency in Pathology and Neuropathology. He is Board Certified in Neuropathology and is Professor of Pathology, Psychiatry, Medical and Molecular Genetics, Neurology, Distinguished Professor of Indiana University, and Chancellor's Professor of Indiana University-Purdue University. He founded the Indiana Alzheimer Disease Center and served as its First Director for 23 years. He served as 58th President of the AANP and 16th President of the ISN. He is the Founder of ISFTD and served as its First President. His seminal work in neuroscience helped deciphering the neuropathology and genetics of hereditary dementias and continues with groundbreaking studies of the structure of the filament core of tau and a-synuclein in human neurodegenerative diseases. He is a Fellow of ANA and AAAS, received the NINDS' Javits Neuroscience Investigator Award, an Honorary Doctorate in Medicine from the University of Siena, Italy, the AANP's Award for Meritorious Contribution to Neuropathology, the Alzheimer's Association's Henry M. Wisniewski Award for Lifetime Achievement in AD Research, and the AAN's Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases.

Emanuele Buratti is currently Group Leader of the Molecular Pathology Laboratory at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste and Professor at the University of Trieste. Previously, he studied at the University of Trieste for a B.Sc. in Biology and a Ph.D. in Biochemistry. In 1995, he moved to ICGEB as a Staff Research Scientist. Dr. Buratti principal areas of expertise are the investigation of RNA binding proteins and RNA metabolism in neurodegeneration and metabolic diseases. On these subjects, Emanuele Buratti is the author of more than 160 research papers in peer-reviewed publications and of book articles on these subjects (for a full list see orcid.org/0000-0002-1356-9074). He is Associate Editor at Frontiers in Genetics, Academic Editor at PloS ONE, and part of the Editorial Board at Journal of Biological Chemistry and Molecular and Cellular Neurosciences. He is also a member of the Scientific Committee of the Italian FTD Patient association (AIFTD) and an Expert Panel Member for Research Foundation Flanders (FWO). Homepage: http://www.icgeb.trieste.it/molecular-pathology.html

Dr. Brad Boeve is a consultant in the Department of Neurology and Center for Sleep Medicine at Mayo Clinic in Rochester, Minnesota, and is Professor of Neurology in the Mayo Clinic College of Medicine and Science. He also serves as Chair of the Division of Behavioral Neurology. His clinical and research interests include the non-Alzheimer's degenerative dementias and the neurologically-based sleep disorders, and particular interests in frontotemporal dementia +/- parkinsonism +/- ALS, primary progressive aphasia, corticobasal syndrome, and progressive supranuclear palsy/Richardson's syndrome, among other disorders. He is a member of the International Society for Frontotemporal Dementias, the Medical Advisory Council of the Association for Frontotemporal Degeneration, and the FTD Prevention Initiative. He is co-PI of Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS), co-investigator in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL), and co-PI of the ARFTL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Consortium. He is funded by the National Institute on Aging, National Institute of Neurological Disorders and Stroke, the Little Family Foundation, and the Mangurian Foundation.

Dr. Rosa Rade

1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder.- 2. The neuropsychiatry of frontotemporal dementia.- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia.- 4. Measuring Behavior and Cognition in FTLD.- 5.  Clinical update on C9orf72: FTD, ALS and beyond.- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations.- 7. Neuroimaging in Frontotemporal Lobar Degeneration.- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies.- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration.- 10. Cross-cultural perspectives on frontotemporal degeneration.- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies.- 12. Tau protein and frontotemporal dementias.- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance.- 14.  Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology.- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins.- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models.- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling.- 18. FTLD treatment:  Current Practice and Future Possibilities.