Biology of Depression

Professor Ma-Li Wong, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in neurology at the University of São Paulo, Brazil and psychiatry at the Albert Einstein College of Medicine, New York, and at Yale University. She joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Molecular Neuroendocrinology Unit, Clinical Neuroendocrinology Branch. In 1999 she took up a professorship at the UCLA Department of Psychiatry & Biobehavioral Sciences, later becoming Director of its Neuroendocrine Core, and has been Director of the General Clinical Research Center Core Laboratory since 2002. Her current research focuses on the genomics and genetics of antidepressant treatment. Professor Wong is Associate Editor of Molecular Psychiatry. Professor Julio Licinio, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in medicine at the University of São Paulo, Brazil, endocrinology at the University of Chicago, and psychiatry at Cornell University and Yale University and joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Clinical Research Unit, Clinical Neuroendocrinology Branch. In 1999 he came to UCLA as Professor of Psychiatry & Biobehavioral Sciences and Medicine/Endocrinology. He is Founding President of the International Society of Pharmacogenomics and one of the principal investigators in the NIH Pharmacogenetics and Pharmacogenomics Research Network. His main research interests include the role of leptin in neuroendocrine-immune interactions and pharmacogenomics of antidepressants. Professor Licinio is Editor of The Pharmacogenomics Journal and Molecular Psychiatry.

Classification of Depression: Research and Diagnostic Criteria - DSM-IV and ICD-10
Psychosocial and Environmental Formulations of Depression
The Economic Burden of Depression: Societal and Patient Perspectives
The Spectrum of Depressive Disorder
The Monoamine Theory of Depression
Monoaminergic-based Pharmacotherapy
Lessons of ECT, ICT and Psychosurgery: The Essential Nature of the Centrencephalic Seizure
Current Prognosis of Depression
Treatment of Depression in Medical Illness
Depression and Suicidality in Children and Adolescents
The Biology and Genetics of Suicidality
Geriatric Depression
Co-morbidity of Depression and Substance Abuse
Depression in the Context of Cancer
Treatment of Refractory Patients
Clinical Pharmacology of new classes of antidepressant drugs
Brain Imaging in Depression and Neuropathological Findings
Dysregulation of Circadian Rhythms in Depression: Molecular Mechanisms
Neuropeptidergic Dysfunction in Depression
Depression, Mania, and Thyroid Function: A Story of Intimate Relationships
Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities
Neuroimmune Mediators
Borna Disease Virus
Depression and Heart Disease
Metabolic Consequences of Depression
Genetic Substrates Shared by Depression and Cardiovascular Disease
Antidepressants and suicide: Clinical considerations
Animal Models of Depression
Loss and Deprivation: From Animal Models to Clinical Presentation
Genomics and Depression
Genetic Approaches to Depression: Linkage Studies
Genetic Approaches to Depression: Association Studies
Molecular Effects of Antidepressant Treatment
The Role of Transcription Factors in the Biology of Depression
Pharmacogenetics and Pharmacogenomics of antidepressant drug action
Pharmacogenetics of antidepressant drug metabolism
Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response
Emerging New Treatments
Complementary and Alternative Medicine treatment for Depression
History and Epidemiology of Depression
Depression in Developing Countries
The Experience of Depression

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Biologie in unserer Zeit