Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

One.- Section I: Channels and channel proteins.- 1: Introduction.- 1. Overview: channels and channel proteins.- 2: A pacemaker channel.- 2. The hyperpolarization-activated inward channel and cardiac pacemaker activity.- 3. The hyperpolarization-activated (If) current: autonomic regulation and the control of pacing.- 3: The cardiac Na+ channel.- 4. Current understanding of the structure of the voltage gated sodium channel.- 5. ?-adrenergic regulation of cardiac Na+ channel.- 4: The L-type cardiac Ca2+ channel.- 6. L-type calcium channel structure and function.- 7. L-type Ca channel biophysics.- 8. ?-adrenergic and muscarinic regulation of L-type calcium current.- 9. Regulation of cardiac Ca2+ channels by cGMP and NO.- 5: The cardiac K+ channel.- 10. Diversity of voltage-dependent K channels.- 11. Cloned human heart delayed rectifier K+ channels.- 12. Primary structure and biophysical properties of inward rectifying K+ channel family.- 13. Ca2+-dependent transient outward current in mammalian heart.- 14. Delayed potassium channels in the heart: regulatory and molecular properties.- 15. Muscarinic and purinergic regulation of cardiac K+ channels.- 6: Cardiac Cl? channels.- 16. Chloride channels in heart.- 7: Cardiac ion channels not gated by voltage.- 17. Properties of cardiac ATP-sensitive potassium channels.- 18. Physiological and molecular properties of cardiac gap junctions.- 19.Volume-regulated cardiac ion channels.- 20. Regulation of cardiac activity by ATP, a purine agonist.- Section II: Ion channels in cardiovascular development.- 1.- 21. Developmental aspects of cardiac ion channels.- 22. Developmental changes and regulation of L-type calcium channels of myocardial cells and vascular smooth muscle cells.- Section III: Pharmacology of ion channels.- 1.- 23.Pharmacology of the calcium channel antagonists.- 24. Interactions of calcium antagonists and agonists with calcium channels in muscle cells.- 25. Pharmacological regulation of the cardiac ATP-sensitive K+ channel.- 26. Fatty acids and cardiac K+ channels.- 27. Sodium channels and block.- Section IV: Ion channels and cardiac pathology.- 1.- 28. Afterdepolarizations triggered rhythms and cardiac arrhythmias.- 29. Transient inward current and triggered activity.- 30. The Na+-activated K+ channel.- 31. Regulation of cardiac ATP-sensitive K channels during ischemia, hypoxia and impaired metabolism.- Two.- Section I: Molecular aspects of Ca2+ release.- 1.- 32. Signaling of calcium release in cardiac muscle.- 33. Local calcium transients in voltage-clamped cardiac cells: evoked ‘calcium sparks’.- 34. Sarcoplasmic recticulum ryanodine receptor/Ca2+ release channel: a functional perspective.- 35. Molecular structure of calcium release channels.- Section II: Molecular steps in cardiac relaxation.- 1.- 36. Sarcoplasmic reticulum Ca2+ ATPases.- 37. Molecular structure and function of phospholamban.- 2: Molecular biology and physiology of Na+-Ca2+ exchange.- 38. Na+-Ca2+ exchanger: molecular aspects.- 39. Na/Ca exchanger: molecular and cellular characteristics.- 40. The functional significance of sodium-calcium exchange.- 41.The physiology of the Na-Ca exchange.- 3: Contraction-relaxation regulation.- 42. Regulation of cardiac relaxation.- 43. Evaluation of changes in myofibrillar Ca2+ sensitivity in intact cardiac cells.- 44. ?-Adrenergic receptor-dependent regulation of myocardial contractility.- 45. Ca transport from the cytoplasm and dynamic cellular Ca balance in cardiac myocytes.- Section III: Regulation of cellular Ca2+ by other transporters.- 1.- 46. Regulation ofintracellular protons: role of Na/H exchange in cardiac myocytes.- 2.- 47. Magnesium homeostasis and cardiac cell function.- 3.- 48. Na-K pump: multiple isoforms and their roles in cardiac functions.