Biomolecular Interactions Part B

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

1. Emerging Mechanisms of Targeted Protein Degradation by Molecular Glues 2. Design and use of programmable DNA Hydrogels 3. Oligomerization of membrane receptors: Approaches to measure in live cells 4. Interactions of alpha-synuclein with biomolecules 5. Gel-electrophoresis based method for biomolecular interaction 6. Recombinant centrosome expression in bacterial system 7. Reconstituting CCL5-CCR5 complex for structural and mechanistic analysis 8. Protein engineering and design in ion channel receptors 9. The crosstalk of G-proteinsand phospholipases in cellular signaling 10. Discovery of virus-host interactions using bioinformatics 11. Measuring Ligand-receptor interactions at opioid receptors 12. Label-free cell-based assays to unravel the biomolecular interactions involved in G-protein coupled receptor signaling 13. Measuring ligand-receptorinteractionsusing Atomic Force Microscopy 14. Reconstituting NTS1R signaling complex in lipid nanodisc 15. Proximity labeling methods to study biomolecular interactions 16. Super-resolution Microscopy approaches for monitoring protein trafficking and interaction 17. Interaction of cytosolic proteins with synthetic antibody fragments using NanoBiT assays 18. Reversible cross-linking to detect protein-protein interaction 19. Assays to monitor the activity of atypical chemokine receptors