Crystallography Made Crystal Clear

Arwen Pearson holds a BSc in Biochemistry from the University of Bath and a PhD in Structural Biology from the University of St Andrews. After postdoctoral research in structural enzymology at the University of Minnesota, she began her independent research career at the University of Leeds in the Astbury Centre for Molecular Biology. She is currently a Professor of Experimental Biophysics at the Universität Hamburg. Her work focuses on developing new tools to enable all aspects of time-resolved structural biology. Nicholas Pearce earned an MPhys in Physics in 2008 from the University of Oxford, and a Ph.D. in Systems approaches to Biomedical Sciences in 2013, also from the University of Oxford. His work centres on developing approaches to confidently extract structural information from crystallographic data; this is achieved by combining novel experimental design with novel computational approaches to build statistically robust experimental platforms for studying (heterogeneous regions of) macromolecular crystals. Jeney Wierman received her B.S. in Physics in 2010 from the University of Washington and a PhD in Biophysics from Cornell University in 2016. In 2018, she joined the Structural Molecular Biology Group at the Stanford Synchrotron Radiation Lightsource at SLAC National Accelerator Laboratory where she is currently a staff scientist. Her projects challenge the boundaries of conventional macro molecular crystallography performed at both synchrotrons and x-ray free electron lasers, including methods and equipment development and data analysis.

1. Models and Molecules
2. An Overview of Protein Crystallography
3. Protein Crystals
4. Collecting Diffraction Data
5. From Diffraction Data to Electron Density
6. Obtaining and Judging the Molecular Model
7. Evaluating and Using Crystallographic Models
8. Applications
9. Other Kinds of Macromolecular Models