Handbook of Nuclear Medicine and Molecular Imaging for Physicists - Three Volume Set

Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015. Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.

Volume I: Instrumentation and Images Processing.

1. The History of Nuclear Medicine

2. Basics of Nuclear Physics

3. Basics of Radiation Interaction in Matter

4. Radionuclide Production

5. Radiometry

6. Scintillation Detectors

7. Semiconductor Detectors

8. Gamma Spectroscopy

9. Properties of the Digital Image

10. Digital Image Processing

11. Machine-Learning

12. Image File Structures in Nuclear Medicine

13. The Scintillation Camera

14. Collimators for Gamma Ray Imaging

15. Image Acquisition Protocols

16. Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging

17. Dedicated Tomographic Single Photon Systems

18. Positron Emission Tomography (PET)

19. Dead Time Effects in Nuclear Medicine Imaging Studies

20. Principles of Iterative Reconstruction for Emission Tomography

21. Clinical Molecular PET/CT Hybrid Imaging

22. Clinical Molecular PET/MRI Hybrid Imaging

23. Quality Assurance of Nuclear Medicine Systems

24. Calibration and Traceability

25. Activity Quantification from Planar images

26. Quantitation in Emission Tomography

27. Multicenter studies: Hardware and Software Requirements

28. Pre-Clinical Molecular Imaging Systems

29. Monte Carlo simulations of Nuclear Medicine Imaging Systems

30. Beta and Alpha Particle Autoradiography

31. Principles behind Computed Tomography (CT)

32. Principles behind Magnetic Resonance Imaging (MRI)

Volume II: Dosimetry and Radiation Protection .

1. Introduction to Biostatistics

2. Radiobiology

3. Diagnostic Dosimetry

4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection

5. Tracer Kinetic Modelling and its use in PET Quantification

6. Principles of Radiological Protection in Healthcare

7. Controversies in Nuclear Medicine Dosimetry

8. Monte Carlo Simulation of Photon and Electron Transport in Matter

9. Patient Models for Dosimetry Applications

10. Patient-Specific Dosimetry Calculations

11. Whole Body Dosimetry

12. Personalized Dosimetry in Radioembolization

13. Thyroid Imaging and Dosimetry

14. Bone Marrow Dosimetry

15. Cellular and Multicellular Dosimetry

16. Alpha-Particle Dosimetry

17. Staff Radiation Protection

18. IAEA support to Nuclear Medicine

Volume III: Radiopharmaceuticals and Clinical Applications.

1. Principles behind Radiopharmacy

2. Radiopharmaceuticals for diagnostics: Planar/SPECT

3. Radiopharmaceuticals for diagnostics: PET

4. Radiopharmaceuticals for radionuclide therapy

5. Design Considerations for a Radiopharmaceutical Production Facility

6. Methods and Equipment for Quality Control of Radiopharmaceuticals

7. Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation

8. GMP - rules and recommendations

9. Management of Radioactive Waste in Nuclear Medicine

10. Translation of Radiopharmaceuticals: Mouse to Man

11. Radionuclide Bone Scintigraphy

12. Radionuclide Examinations of the Kidneys

13. Neuroimaging in Nuclear Medicine

14. Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT

15. Myocardiac Perfusion Imaging

16. Infection and Inflammation

17. Special Considerations In Pediatric Nuclear Medicine

19. Antibody-Based Radionuclide Imaging

18. Radionuclide-Based Diagnosis and Therapy of Prostate Cancer

20. Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors

21. Lymphoscintigraphy

22. Diagnostic Ultrasound
Tomas Jansson

23. Clinical Trials - Purpose and Procedures

24. Introduction to Patient Safety and Improvement Knowledge

25. Closing remarks