Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

lt;br>Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany. 

Overview.- Foreign Compounds: Foods, Drugs and Other Chemicals.- Absorption, Metabolism and Excretion of Foreign Compounds.- Metabolism of Foreign Compounds.- Bioactivation Metabolism: Activation Enzymes.- Functionalization Reactions Catalyzed by Activation Enzymes.- Detoxifying Metabolism: Detoxification Enzymes.- Conjugation Reactions Catalyzed by Detoxification Enzymes.- Reactive Intermediates Generated from Bioactivation.- Electrophilic Nature of Metabolic Reactive Intermediates.- Oxidative Stress Mediated by Reactive Intermediates.- Xenobiotics Bioactivation - Mediated Cellular Damages.- Nrf2 - ARE Pathway: Defense Against Oxidative Stress.- Genetic Variations and Polymorphisms of Metabolic Enzymes.- Enzyme Polymorphisms Affecting Xenobiotic Toxicity.- Inducibility of foreign Compound Metabolic Enzymes.- Induction of Enzymes for Health Benefits.- Diversity of Metabolic Enzyme Modulators.- Dietary Inducers of Detoxification Enzymes.