Clinical Use of Anti-infective Agents

Robert W. FinbergRichard Haidack Professor and ChairDepartment of MedicineUniversity of MassachusettsMedical SchoolWorcester, MA, USA
Robert.Finberg@umassmed.edu
Roy GuharoySystem Vice PresidentBaptist Health System, Montgomery, ALUMass Memorial Health Care Clinical Professor of Medicine University of Massachusetts Medical School Worcester, MA, USA Roy.Guharoy@umassmemorial.org

1. Introduction and history.- 2. Basic principles of drug delivery and dosing.- 3. Sulfonamides.- 4. Penicillins.- 5. Cephalosporins.- 6. Monobactams: Aztreonam.- 7. Carbapenems.- 8. Glycopeptides and other agents used to treat gram-positive cocci.- 9. Vancomycin: New Area-under-the-curve-based therapeutic monitoring.- 10. Aminoglycosides.- 11. Macrolides.- 12. Metronidazole and clindamycin.- 13. Quinolones.- 14. Tetracyclines.- 15. Pleuromutilin.- 16. Antimicrobial stewardship: evolution into the 21st century.- 17. Clinical approach to the treatment of infectious diseases.- 18. Understanding drug allergies and drug toxicities.- 19. Antibiotic-associated diarrhea.- 20. Principles of antibiotic resistance.- 21. Clinical approach to treatment of bacterial infections.- 22. Clinical approach to treatment of mycobacterial infections.- 23. Clinical approach to treatment of fungal infections.- 24. Clinical approach to treatment of viral infections.- 25. Sample cases and analyses of the use ofanti-infective agents: Cases 1-15.- Appx A. Common infectious diseases and empiric antibiotic recommendations for adult ed and inpatients at UMass Memorial Medical Center.- Appx B. Bioavailability of anti-infective agents.- Appx C. Dosage and intervals for administration of IV antimicrobials.- Appx D. Dosage and intervals for administration of oral antimicrobials.- Appx E. Important interactions with commonly-used anti-infectives.- Appx F. Oral agents that may have interactions with food.- Appx G. Drug interactions with anti-retroviral agents.- Appx H. Dosage in obesity.- Appx I. Recommendations for management of Asymptomatic Bacteriuria (ASB): 2019 update.- Appx J. Guidelines for treatment of C. difficile.- Appx K. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression.- Appx L. Guidelines for treatment of adults with community-acquired pneumonia.- Appx M. Guidelines for management of adults with hospital-acquired and ventilator-associated pneumonia.- AppxN. Guidelines for antimicrobial prophylaxis for surgery.- Appx O. Guidelines for treatment and chemoprophylaxis of influenza.- Appx P. Antimicrobial dosing in adult patients on extracorporeal membrane oxygenation (EXMO).- Appx Q. Antimicrobial dosing in neonates.