Design and Delivery of SiRNA Therapeutics

RNA Interference: Story and Mechanisms.- Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-target Effect.- Stick-based Methods for Aptamer-mediated siRNA Targeted Delivery.- Evaluation of siRNA Stability and Interaction With Serum Components Using an Agarose Gel-Based Single-Molecule FRET Labeling Method.- Development of siRNA Therapeutics for the Treatment of Liver Diseases.- siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.- Synthesis of GalNAc-Oligonucleotide Conjugates Using GalNAc Phosphoramidite and Triple-GalNAc CPG Solid Support.- Preparation of Lipid-Conjugated siRNA Oligonucleotides for Enhancing Gene Inhibition in Mammalian Cells.- Engineering of Solid Dosages Forms of siRNA-loaded Lipidoid–Polymer Hybrid Nanoparticles using a quality by Design Approach.- Preparation and Characterization of siRNA-loaded Liposomes.- SiRNA Vehicles for High Endosomal Escapability.- SiRNA Design andDelivery Based on Carbon Nanotubes.- MRI-Visible Nanovehicle for Efficient siRNA Delivery.- Cationic Dendrimers for siRNA Delivery: An Overview of Methods for in Vitro / In Vivo Characterization.- ITC for Characterization of Self-Assembly Process of Cationic Dendrons for siRNA Delivery.- Cationic Dendrimers for siRNA Delivery - Computational Approaches for Characterization.- Fundamental and Practical Aspects in the Formulation of Colloidal Polyelectrolyte Complexes of Chitosan and siRNA.- Cell-Penetrating Peptides Delivering siRNAs: An Overview.- Non-Covalent Encapsulation of siRNA with Cell-penetrating Peptides.- siRNA Therapeutics for Protein Misfolding Diseases of the Central Nervous System.- siRNA Loaded-exosomes.- Production and Characterization of Anti-CCR5 siRNA-Loaded Polycaprolactone Nanoparticles for Topical Pre-Exposure Prophylaxis.- siRNA Therapeutics in Ocular Diseases.- Delivery of siRNA to the Eye: Protocol fora Feasibility Study to Assess Novel Delivery System for Topical Delivery of siRNA Therapeutics to the Ocular Surface.