Carcinogen-Driven Mouse Models of Oncogenesis

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.

1. Preface - Chemical carcinogenesis in mice as a model of human cancer: Pros and cons Lorenzo Galluzzi 2. MPA/DMBA-driven mammary carcinomas Aitziber Buqué Martinez 3. Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice Isabelle Plante 4. Urethane-induced lung carcinogenesis Silvano Sozzani 5. Methylcholanthrene-induced fibrosarcomas Awen Gallimore 6. BBN-driven bladder carcinomas Janos Terzic 7. Oral squamous cell carcinomas driven by 4NQO Nancy J. Philp 8. Analysing skin tumor development in mice by the DMBA/TPA model Cord Brakebusch 9. DSS/AOM-driven colorectal carcinomas David C. Montrose 10. Diethylnitrosamine-induced liver tumorigenesis in mice Peter Hasselblatt 11. Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice Alison K. Bauer 12. Lung carcinomas induced by NNK and LPS Peter Di 13. Pristane-induced mammary carcinomas Bae Hoon Lee 14. The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis Pierre Saintigny