Non-covalent Interactions In Proteins

Dr Andrey Karshikoff is Professor Emeritus and formerly Director of the Institute of Molecular Biology at the Bulgarian Academy of Sciences. He holds a PhD in Biophysics from Sofia University, Bulgaria. After the political changes in Bulgaria he was able to move to Max-Planck Institute for Biochemistry, Germany, where he spent several years as Alexander-von-Humboldt and Max-Planck Fellow. He continued his research as Associate Professor at Karolinska Institute, Sweden. His research was in the field of structure-function relationships in proteins. He has 20 years of experience in teaching undergraduate and graduate students. He has published over 70 papers in reputed journals such as Journal of Molecular Biology, Biochemistry, Protein Science, Journal of Chemical Physics, Trends in Biochemical Sciences, and others. He is proficient in 6 languages.

Dedication; Preface to the First Edition; Preface to the Second Edition; Introduction:Some Historical Notes; Overview of Protein Structural Elements and Basic Definitions; Non-Covalent Interactions and Structure-Function Relationships in Proteins; Van der Waals Interactions:Observation of van der Waals Interactions; Nature of van der Waals Interactions; Potential Functions for Application in Proteins; Approximation for Polyatomic Systems; Hydrogen Bonds:Nature of Hydrogen Bonds; Geometry and Strength of Hydrogen Bond; Hydrogen Bonds in Proteins; Hydrogen Bonds and Protein Stability; Hydrophobic Interactions:Nature of Hydrophobic Interactions, Pseudo Forces; Water; Hydrophobic Effect; Hydrophobic Interactions in Proteins; Electrostatic Interactions:Debye-Hückel Theory; Ion-solvent Interactions; Calculation of Electrostatic Interactions in Proteins; Ionization Equilibria in Protein:Why Does One Need to Know Ionisation Equilibria?; Basic Definitions; Factors Determining Ionisation Equilibria in Proteins; Combinatorial Problem; Cooperative Ionization; Conformational Flexibility:Location Variation of Polar Hydrogen Atoms; Examples for Ph-Dependent Hydrogen Bonding; Conformational Flexibility Involving Non-hydrogen Atoms; Protein States:Folded and Unfolded States; Misfolded Proteins; Metamorphic Proteins; Intrinsically Disordered Proteins; Modelling of Electrostatic Interactions in Unfolded Proteins:Spherical Model of Unfolded Proteins; Size of the Dielectric Sphere; Average Distance Between Charges; Ionisation Equilibria in Unfolded Proteins; Protein Stability:Definitions; Kinetic Stability; pH Dependence of Protein Stability; Temperature Dependence of Protein Stability; Thermal Stability of Proteins; Appendix A: Basic Concepts in Thermodynamics and Statistical Physics:Subject and Main Definitions of Thermodynamics; Subject and Main Definitions of Statistical Thermodynamics; Appendix B: Electric Dipoles:Definition; Electrostatic Field of a Dipole; Appendix C: Nabla-operator, Solutions of the Poisson-Boltzmann Equations:Laplace Operator; Spherical Symmetrical Form of the Laplace and Poisson-Boltzmann Equations; Solution of Laplace and Poisson-Boltzmann Equation in the Debye-Hückel Theory; Index;