Protein Interactions

Volkhard Helms has been a full professor for bioinformatics at Saarland University since 2003. He received a Ph.D. for research done at EMBL Heidelberg, did post-doctoral work at UC San Diego, and subsequently was an independent group leader at the Max Planck Institute of Biophysics in Frankfurt. Professor Helms has authored about 200 scientific publications. In 2000, he was named an EMBO Young Investigator. Olga Kalinina is a professor for drug bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland since 2019. She received a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences in 2007, did post-doctoral work at EMBL Heidelberg and University of Heidelberg (2007-2011) and subsequently was a group leader at the MPI for informatics in Saarbrücken (2012-2018). Prof. Kalinina has authored over 40 scientific publications.

Protein Structure and Conformational Dynamics
Protein-Protein Binding Interfaces
Correlated Co-evolving Mutations at Protein-Protein Interfaces
Protein-Protein-Docking
Identification of Putative Protein Complexes in Protein-Protein Interaction Networks
Structures, Composition, and Modelling of Protein Complexes
Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function
Kinetics and Thermodynamics of Protein-Protein Encounter
Markov-State Models for Protein-Protein Encounter
Transcription Factor-DNA Complexes
Chromatin Interactomics
Interactions of Proteins with mRNA and ncRNA
Interactions Between Proteins and Biological Membranes
Interactions of Proteins with Small Molecules
Effects of Mutations in Proteins on Their Interactions
Not Quite the Same: How Alternative Splicing Affects Protein Interactions
Phosphorylation-based Molecular Switches
Summary and Outlook