The Lock-and-Key Principle

Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

Contributors vii

Preface ix

1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1

Friedrich Cramer

2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25

Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir

3 New Biocatalysts via Chemical Modification 73

Ian M. Bell and Donald Hilvert

4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89

V. V. Vlassov

5 Macrocycles and Antibodies as Catalysts 149

D. B. Smithrud and S. J. Benkovic

6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173

Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav

7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247

H. Kuhn and J. Waser

8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307

Jean-Marie Lehn

Index 319