The TNF Superfamily

Signaling in TNFSF15-mediated Suppression of VEGF Production in Endothelial Cells.- Sensitization of Airway Epithelial Cells to Toxin-Induced Death by TNF Superfamily Cytokines.- Inhibition of Chondroitin Sulfate Proteoglycans by APRIL.- Induction of Antigen-independent Proliferation of Regulatory T-cells by TNF superfamily ligands OX40L and GITRL.- Transition from TNF-induced Inflammation to Death Signaling.- Analysis of FcgR-Dependent Agonism Of Antibodies Specific for Receptors of the Tumor Necrosis Factor (TNF) Receptor Superfamily (TNFRSF).- Generation and Evaluation of Bispecific anti-TNF Antibodies Based on Single-Chain VHH Domains.- In Vitro Physical and Functional Interaction Assays to Examine the Binding of Progranulin Derivative Atsttrin to TNFR2 and its anti-TNFα activity.- Fluorescence Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators.- Production of Multi-Subtype Influenza Virus-Like Particles by Molecular Fusion with BAFF or APRIL for Vaccine Development.- Experimental Methods for the Immunological Characterization of Paradoxical Psoriasis Reactions Induced by TNF-α Biologics.- Methods for the Administration of EDAR Pathway Modulators in Mice.- Analysis of Ligand-Receptor Interactions Using Bioluminescent TNF Superfamily (TNFSF) Ligand Fusion Proteins.- Monitoring Atsttrin-mediated Inhibition of TNFα/NF-κβ Activation through in vivo Bioluminescence Imaging.- The use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis.- Identification of CD137- and CD137L-expressing Cells in EL-4 Tumor.- -Expression Profiling of Tumor Necrosis Factor Superfamily Ligands mRNA in Healthy and Injured Murine Kidneys.- Analysis of Lymphotoxin Alpha Expression in Human Retina and Generation of Expression Vectors to Functional Characterization of Polymorphisms in the Tumor Necrosis Factor Locus.- Detection of TNF-α Protein in Extracellular Vesicles Derived from Tumor Cells by Western Blotting.- Expression of TNFRs by B and T lymphocytes in Tumor-Draining Lymph Nodes.- Methods for Evaluation of TNF-α Inhibition Effect.