Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B

David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Co-Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.

Preface 

David Teplow 

1. Relevance of transgenic mouse models for Alzheimer's disease 

Leon Tai, Juan Maldonado Weng, Mary Jo LaDu and Scott Brady 

2. Mitochondrial transplant to replenish damaged mitochondria: A novel therapeutic strategy for neurodegenerative diseases?

Abhisek Mukherjee, Andrea D Becerra Calixto, Melissa Chavez, Jean Paul Delgado Charris and Claudio Soto 

3. Activity-dependent neuroprotective protein (ADNP)-end-binding protein (EB) interactions regulate microtubule dynamics toward protection against tauopathy 

Yanina Ivashko-Pachima and Illana Gozes 

4. Applying available knowledge and resources to alleviate familial and sporadic neurodegenerative disorders 

Mark P. Mattson 

5. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? 

Lawrence S.B. Goldstein and Utpal Das 

6. The search for novel targets in Alzheimer's disease—The 90s redux 

Christian Behl 

7. Adult hippocampal neurogenesis in Alzheimer's disease 

Ahmed Disouky and Orly Lazarov 

8. Early detection and personalized medicine: Future strategies against Alzheimer's disease 

Antonio Di Meco and Robert Vassar 

9. Inflammation and Parkinson’s disease pathogenesis: Mechanisms and therapeutic insight 

Gianluigi Forloni, Pietro la Vitola, Milica Cerovic and Claudia Balducci