Process Scale Bioseparations for the Biopharmaceutical Industry

Abhinav A. Shukla, Mark R. Etzel, Shishir Gadam

Harvest of a Therapeutic Protein Product from High Cell Density Fermentation Broths: Principles and Case Study; E. Russell, A. Wang, and A.S. Rathore
Expanded Bed Adsorption for Capture from Crude Solution; A. Sonnenfeld and J. Thömmes
Product Recovery by High-Gradient Magnetic Fishing; M. Franzreb, N. Ebner, M. Siemann-Herzberg, T.J. Hobley, and O.R.T. Thomas
Protein Refolding and Scale Up; C. Cowgill, A. Ozturk, and R. St. John
Bulk Protein Crystallization-Principles and Methods; M.R. Etzel
Modes of Preparative Chromatography; A.A. Shukla and Y. Yigzaw
Screening of Chromatographic Stationary Phases; A.A. Shukla and X.S. Han
A Priori Prediction of Chromatographic Separations from Protein Structure Data; A. Ladiwala, C.M. Breneman, and S.M. Cramer
Membrane Chromatography: Analysis of Breakthrough Curves and Viral Clearance; M.R. Etzel and W.T. Riordan
Ultrafiltration Process Design and Implementation; H. Lutz and B. Raghunath
Virus Filtration Process Design and Implementation; M.W. Phillips, G. Bolton, M. Krishnan, J.J. Lewnard, and B. Raghunath
Product Recovery from Transgenic Sources; C. Zhang and K.E. Van Cott
Analytical Strategy for Biopharmaceutical Development; D.N. Kelner and M.K. Bhalgat
Evaluation of Viral Clearance in Purification Processes; A. Kundu and K. Reindel
Advances in Viral Clearance; K. Brorson
Protein A Affinity Chromatography for Capture and Purification of Monoclonal Antibodies and Fc-Fusion Proteins: Practical Considerations for Process Development; S. Ghose , T. McNerney, and B. Hubbard
Polishing Methods for Monoclonal IgG Purification; P. Gagnon
Making Changes to a Biopharmaceutical Manufacturing Process During Development and Commercial Manufacturing: The REMICADE® Story; P.W. Wojciechowski, H.I. Smit, M.M. Myers,
P.J. Voronko, T. Laverty, R. A. Ramelmeier, and R.C. Siegel
Linear Scale-Up of Ultrafiltration of High Viscosity Process Streams; C. Daniels, B. Gierl, P.K. Yegneswaran, M.G. Gayton, A.L. Lee, N.S. Pujar, M. Perreault, D. Serway, and J. Rozembersky
A Membrane Chromatography Application: A Rapid, High Capacity Gene Therapy Vector Purification Tool; A.R. Lajmi, R. Kutner, and J. Reiser
Index