Classics in Total Synthesis IV – New Targets, Strategies, and Methods

K.C. Nicolaou is Harry C. and Olga K. Wiess Professor of Chemistry in the BioScience Research Collaborative at Rice University, Houston. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology. For his contributions to science and education, he was elected Fellow of the New York Academy of Sciences, Fellow of the American Academy of Arts and Sciences, Member of the National Academy of Sciences, USA, Member of the German Academy of Sciences Leopoldina, and Corresponding Member of the Academy of Athens, Greece. He is the author or co-author of more than 790 scientific articles, reviews, and book chapters, 79 patents, and five books, including the popular Classics in Total Synthesis co-authored with his student E.J. Sorensen (1996, VCH), Classics in Total Synthesis II co-authored with his student S.A. Snyder (2003, Wiley-VCH), Classics in Total Synthesis III co-authored with his student J.S. Chen (2011, Wiley-VCH), and Molecules That Changed the World, co-authored with his research associate T. Montagnon (2008, Wiley-VCH). His dedication to chemical education is evidenced by his training of hundreds of graduate students and postdoctoral fellows. Ruocheng Yu studied chemistry at Peking University, China where he received his B.S. degree under the supervision of Zhen Yang and Jiahua Chen in 2012 before he went to pursue his doctoral studies under the guidance of K.C. Nicolaou at the Scripps Research Institute and later Rice University. He graduated in 2017 and is the recipient of several honors such as The American Institute of Chemists Student Award, the Harry B. Weiser Teaching Award and the John L. Margrave Thesis Award and is currently a postdoctoral fellow in K. C. Nicolaou's research group. Stephan Rigol was educated at Leipzig University, Germany where he obtained his undergraduate degrees and received his doctorate in 2013. He then moved to the United States to join the group of K.C. Nicolaou at Rice University where he is currently conducting research in the field of natural products chemistry as a postdoctoral fellow.

1. Introduction: Total Synthesis Marching on with New Methods and Strategies and with Molecules for Biology and Medicine
2. Halichondrin B and Norhalichondrin B
3. Daphmanidin E
4. Epicoccin G and (-)-Acetylaranotin
5. Taiwaniadducts B, C, and D
6. Schindilactone A
7. Welwitindolinones
8. Ryanodine and Ryanodol
9. Gedunin, Mitrephorone A, and Antiretroviral Agent Islatravir
10. Trioxacarcins
11. Aplyviolene
12. Dixiamycin B
13. Ingenol
14. Cardamom Peroxide, Nodulisporic Acid C, and Bilobalide
15. Batrachotoxin and Conidiogenones
16. Gukulenin B and C-H Functionalization