The Macrophage as Therapeutic Target

List of Contents.- 1. General.- The Macrophage as a Validated Pharmaceutical Target.- Transcription Factors that Regulate Macrophage Development and Function.- Exploitation of Macrophage Clearance Functions In Vivo.- Reaching the Macrophages: Routes of Delivery.- Antigen Presenting Cells and Vaccine Design.- Macrophage-Specific Gene Targeting In Vivo.- 2. Macrophage Targets in Inflammation.- Integrins of Macrophages and Macrophage-Like Cells.- Macrophage Targets in Inflammation: Purinergic Receptors.- Macrophage Lipid Uptake and Foam Cell Formation.- Dietary Fatty Acids and Macrophages.- Macrophages as Therapeutic Targets in Lysosomal Storage Disorders.- Nuclear Receptors as Regulators of Macrophage Homeostasis and Function.- Relationships between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages.- Proteases.- Targeting the Chemokine System.- Antimicrobial Peptides.- Macrophage Phospholipid Products.- 3. Modulation of Specialised Macrophage Activities.- Dendritic Cells Versus Macrophages as Antigen-Presenting Cells: Common and Unique Features.- The Osteoclast.- Macrophages in the Central and Peripheral Nervous System.- Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligand for Antiviral Agents.- Macrophage Immunity and Mycobacterium Tuberculosis.- Detection and Control of Fungi by Macrophages: The Role of Carbohydrates and Antifungal Agents.