Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Part 1. Fundamentals of quadruplexes and their biology





Fundamentals of G-quadruplex biology
F. Brad Johnson

Quadruplex structure and diversity
Fernaldo Richtia Winnerdy and Anh Tuân Phan

Part 2. Quadruplex targets in human and other organisms

Telomeric quadruplexes as therapeutic targets
Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy
Emanuela Ruggiero and Sara N. Richter

Quadruplex detection in human cells
David Monchaud

Part 3. Discovery and design of quadruplex-binding compounds

An overview of quadruplex ligands: Their common features and chemotype diversity
Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria

Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding
Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider

Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers
Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou

Click and combinatorial approaches to quadruplex ligand discovery
Jyotirmayee Dash, Puja Saha and Khushnood Fatma

Quadruplex nucleic acids in KRAS targeted-cancer therapy
Luigi E. Xodo

Transcriptional regulation of MYC through G-quadruplex structures
Sumirtha Balaratnam and John S. Schneekloth

KIT promoter: Structure, function and targeting
Silvia Ceschi and Claudia Sissi

Quadruplex targets in neurodegenerative diseases
Janez Plavec

Metal complexes as G-quadruplex binders
Tim Kench and Ramon Vilar

Challenges in developing small-molecule quadruplex therapeutics


Stephen Neidle