Urinary Tract Infections (eBook)

Contributors ix

Foreword xvii

Preface xix

I. Clinical Aspects of Urinary Tract Infections

1 Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection 3
Duane R. Hickling, Tung-Tien Sun, and Xue-Ru Wu

2 Clinical Presentations and Epidemiology of Urinary Tract Infections 27
Suzanne E. Geerlings

3 Diagnosis, Treatment, and Prevention of Urinary Tract Infection 41
Paula Pietrucha-Dilanchian and Thomas M. Hooton

4 Urinary Tract Infections in Infants and Children 69
Theresa A. Schlager

5 The Vaginal Microbiota and Urinary Tract Infection 79
Ann E. Stapleton

6 Asymptomatic Bacteriuria and Bacterial Interference 87
Lindsay E. Nicolle

7 Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions 121
John N. Krieger and Praveen Thumbikat

8 Urosepsis: Overview of the Diagnostic and Treatment Challenges 135
Florian M. E. Wagenlehner, Adrian Pilatz, Wolfgang Weidner, and Kurt G. Naber

II. Origins and Virulence Mechanisms of Uropathogenic Bacteria

9 Reservoirs of Extraintestinal Pathogenic Escherichia coli 161
Amee R. Manges and James R. Johnson

10 Origin and Dissemination of Antimicrobial Resistance among Uropathogenic Escherichia coli 179
Lisa K. Nolan, Ganwu Li, and Catherine M. Logue

11 Population Phylogenomics of Extraintestinal Pathogenic Escherichia coli 207
Jérôme Tourret and Erick Denamur

12 Virulence and Fitness Determinants of Uropathogenic Escherichia coli 235
Sargurunathan Subashchandrabose and Harry L. T. Mobley

13 Uropathogenic Escherichia coli-Associated Exotoxins 263
Rodney A. Welch

14 Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria 277

Peter Chahales and David G. Thanassi

15 Pathoadaptive Mutations in Uropathogenic Escherichia coli 331
Evgeni Sokurenko

16 Invasion of Host Cells and Tissues by Uropathogenic Bacteria 359
Adam J. Lewis, Amanda C. Richards, and Matthew A. Mulvey

17 Proteus mirabilis and Urinary Tract Infections 383
Jessica N. Schaffer and Melanie M. Pearson

18 Epidemiology and Virulence of Klebsiella pneumoniae 435
Steven Clegg and Caitlin N. Murphy

19 Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract 459
Kimberly A. Kline and Amanda L. Lewis

20 Integrated Pathophysiology of Pyelonephritis 503
Ferdinand X. Choong, Haris Antypas, and Agneta Richter-Dahlfors

III. Host Responses to Urinary Tract Infections and Emerging Therapeutics

21 Susceptibility to Urinary Tract Infection: Benefits and Hazards of the Antibacterial Host Response 525
Ines Ambite, Karoly Nagy, Gabriela Godaly, Manoj Puthia, Björn Wullt, and Catharina Svanborg

22 Innate Immune Responses to Bladder Infection 555
Byron W. Hayes and Soman N. Abraham

23 Host Responses to Urinary Tract Infections and Emerging Therapeutics: Sensation and Pain within the Urinary Tract 565
Lori A. Birder and David J. Klumpp

24 Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections 589
Valerie P. O'Brien, Thomas J. Hannan, Hailyn V. Nielsen, and Scott J. Hultgren

Index 647

The editors of this tour de force of
urinary tract biology have recruited the field's top thought leaders to
contribute chapters covering all aspects of the discipline. This outstanding
text encompasses everything from the newest theories regarding basic
pathogenesis of urinary tract infections, to broad insights into the
epidemiology of bacterial uropathogens, and the latest in translational
research on new vaccine and therapeutic candidates.

-Michael Hsieh, MD, PhDlang=EN-CA>, Stirewalt Endowed Director, Biomedical Research Institute; PI,
Schistosomiasis Resource Center and The Bladder Immunology Group (BIG);
Associate Professor of Urology and Pediatrics, George Washington University;
Director, CAPITUL, Children's National Medical Center