Human Pluripotent Stem Cell Derived Organoid Models

Jason R. Spence, PhD, is an Associate Professor of Internal Medicine, Cell and Developmental Biology and Biomedical Engineering at the University of Michigan Medical School. He attended Canisius College in Buffalo, NY, as an undergraduate. He attended graduate school at Miami University (Ohio) where his research focused on understanding mechanisms that drive regeneration and tissue repair in unique model organisms that maintain regenerative ability throughout life, including Notophthalmus viridescens (Eastern Newt), Ambystoma mexicanum (Axolotl) and the chick. He performed postdoctoral research Cincinnati Children’s Hospital, where he turned his focus to understanding mechanisms that regulate embryonic development of endoderm-derived tissue (pancreas, liver, intestine) and utilized human pluripotent stem cells (hPSCs) to understand human differentiation and development. During this time, he pioneered methods to differentiate 3-dimensional intestinal organoids from human pluripotent stem cells. In 2011, Dr. Spence joined the faculty of the University of Michigan Medical School. The focus of the Spence lab include using 3-dimensional organoid human models to study human development and disease, with research focused on understanding intestinal, lung and esophageal development, homeostasis and disease.

1. Pluripotent stem cell derived gastric organoids Yana Zavros 2. Pluripotent stem cell derived esophageal organoids James Wells 3. Pluripotent stem cell derived small intestinal organoids David R. Hill 4. Pluripotent stem cell derived colonic organoids Jorge Munera 5. Pluripotent stem cell intestinal organoids with an Enteric Nervous System Maxime Mahe 6. Pluripotent stem cell derived airway organoids Finn Hawkins 7. Pluripotent stem cell derived alveolar organoids Shimpei Gotoh 8. Pluripotent stem cell derived liver bud organoids Takanori Takebe 9. Pluripotent stem cell derived thyroid organoids Sabine Costagliola 10. Pluripotent stem cell derived renal organoids Jennifer Harder 11. Pluripotent stem cell derived cerebral organoids Gray Camp 12. Generating ventral spinal organoids from human induced pluripotent stem cells Shi Yan Ng 13. Pluripotent stem cell derived retinal organoids Jason Meyer 14. Pluripotent stem cell derived inner ear organoids Eri Hashino 15. Pluripotent stem cell derived skin Karl R. Koehler 16. Pluripotent stem cell derived cholangiocytes and cholangiocyte Organoids Anne Dubart-Kupperschmitt