Mapping of Nervous System Diseases via MicroRNAs -

Mapping of Nervous System Diseases via MicroRNAs

Buch | Softcover
262 Seiten
2019
CRC Press (Verlag)
978-0-367-87115-4 (ISBN)
68,55 inkl. MwSt
This book provides an up-to-date review of the function of microRNA (miRNA) in neurological diseases as well as advancements in technology for therapeutic modulation of miRNA activity. It covers general concepts and novel insights on brain function in relation to miRNA and also examines the role of miRNAs in various neurological diseases. Coveri
In recent years, understanding of microRNA (miRNA) biogenesis, the molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has expanded. Mapping of Nervous System Diseases via MicroRNAs provides an up-to-date review on the function of miRNA in neurological diseases as well as advancements in technology for therapeutic modulation of miRNA activity.



MicroRNAs are small RNA molecules that regulate gene expression post-transcriptionally. A growing body of evidence suggests that miRNAs are dysregulated in several neurological disorders. In addition to reviewing general concepts and novel insights on brain function in relation to miRNA, this book also examines the role of miRNA in:








Neurological diseases



Neurodegenerative diseases



Neuropsychiatric diseases



Neurodevelopmental diseases



The book also discusses the significance of miRNAs as diagnostic tools, biomarkers, agents, and targets in the detection and treatment of neurological diseases. Each chapter contains material regarding future diagnostic and therapeutic advances.



Molecular and cellular neurobiological studies of miRNA-mediated gene silencing in the nervous system have opened new frontiers for the development of new diagnostic tests and genetic therapies for neurological diseases. Covering the full range of relevant concepts and giving a look into present and future possibilities, Mapping of Nervous System Diseases via MicroRNAs is a necessary cutting-edge reference for neurologists, neuropathologists, and researchers and practitioners in a wide range of related fields.

Christian Barbato, MD, is a researcher at the Institute of Cell Biology and Neurobiology, CNR, in Italy. He earned his PhD in neuroscience from the University of Rome Tor Vergata, Italy. His past work has focused on the characterization of cellular and molecular neurobiology of RNA-induced silencing complex and noncoding RNA in synaptic plasticity, learning, and memory. His recent research focuses on the function of microRNAs and their gene targets implicated in physiological and pathological processes of neurons. Francesca Ruberti, PhD, is a researcher at the Institute of Cell Biology and Neurobiology, CNR, in Italy. He earned his PhD in biophysics from the International School of Advanced Studies, Trieste, Italy. His past research has focused on the role of nerve growth factor on specific neuronal populations of the central nervous system and on synaptic plasticity in the hippocampus, and on the molecular mechanisms involved in the cellular localization of specific neuronal proteins or messenger RNAs. His recent research focuses on the study of microRNAs and their gene targets implicated in physiological and pathological processes of neurons.

MicroRNAs IN THE NERVOUS SYSTEM AND NEUROLOGICAL DISEASES (BASIC): MicroRNAs IN THE NERVOUS SYSTEM. MicroRNA Biology and Function in Nervous System. MicroRNAs IN THE NERVOUS SYSTEM AND NEUROLOGICAL DISEASES (BASIC): MicroRNAs IN NEUROPSYCHIATRIC DISEASES. MicroRNAs in Mood and Anxiety Disorders. MicroRNA Dysregulation in Schizophrenia and Functional Consequences. The Impact of MicroRNAs in Synaptic Plasticity, Major Affective Disorders, and Suicidal Behavior. MicroRNAs IN THE NERVOUS SYSTEM AND NEUROLOGICAL DISEASES (BASIC): MicroRNAs IN NEUROLOGICAL DISEASES. MicroRNAs in Prion Diseases. MicroRNAs in Epileptogenesis and Epilepsy. MicroRNAs and Pain. MicroRNA BIOMARKERS IN NEUROLOGICAL DISEASES (APPLICATIONS). Circulating Cell-Free MicroRNAs as Biomarkers for Neurodegenerative Diseases. Circulating Cell-Free MicroRNAs as Biomarkers for Neural Development and Its Importance in Fetal Programming for Postnatal Disease.

Erscheinungsdatum
Reihe/Serie Frontiers in Neurotherapeutics Series
Verlagsort London
Sprache englisch
Maße 156 x 234 mm
Gewicht 453 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 0-367-87115-7 / 0367871157
ISBN-13 978-0-367-87115-4 / 9780367871154
Zustand Neuware
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