Long-lived Proteins in Human Aging and Disease

Roger J. W. Truscott (Herausgeber)

Buch | Hardcover
224 Seiten
2021 | 1. Auflage
Wiley-VCH (Verlag)
978-3-527-34728-5 (ISBN)
125,00 inkl. MwSt
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This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

  • New insight on a key issue in human biology: New research shows that how the aging of long-lived proteins in the human body is directly related to age-related diseases.
  • First comprehensive overview: The current literature on mechanisms of aging does not cover protein aging in any detail. This is the first authoritative overview on the topic.
  • Includes method descriptions: Detection and analysis methods for long-lived proteins and their decay are also covered, enabling researchers to quickly make progress in this emerging field.

Roger Truscott is a Research Professor at the Illawarra Health and Medical Research Institute, University of Wollongong. Having obtained his PhD at Melbourne University, he has spent most of his academic career working for the University of Sydney and the University of Wollongong. He has authored over 200 scientific publications. His main field of research is human aging with particular reference to age-related diseases, such as cataract. He has received numerous awards including a senior NHMRC fellowship and the National Foundation for Eye Research (USA) Cataract Research Award.

Modification of Long-lived Proteins and Protein Insolubility
Chaperones as Agents that Detect and Bind to Modified Long-lived Proteins
Autophagy and Proteostasis
Comparison of PTMs of Long-lived Proteins from Various Tissues
Imaging Methodologies to Visualise Long-lived Proteins
Glycosylation and Other PTMs of Long-lived Proteins
Human Aging and Long-lived Proteins

Erscheinungsdatum
Verlagsort Weinheim
Sprache englisch
Maße 170 x 244 mm
Gewicht 574 g
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie Organische Chemie
Schlagworte Alterung • Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Cell & Molecular Biology • Cellular & Molecular Medicine • Cellular & Molecular Medicine • Chemie • Chemistry • Life Sciences • Medical Science • Medizin • Proteine • Zell- u. Molekularbiologie • Zell- u. Molekularmedizin
ISBN-10 3-527-34728-3 / 3527347283
ISBN-13 978-3-527-34728-5 / 9783527347285
Zustand Neuware
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