Novel Therapeutic Advances in Glioblastoma

Igor Bryukhovetskiy is at Far Eastern Federal University, Russia Aruna Sharma, MD is currently Secretary of Research at Uppsala University Hospital, Uppsala University, Sweden. She obtained her Bachelor of Science in 1971 and trained in Indian Medicine up to 1977 and engaged in medical research from 1978 to 1986 in India on hyperthermia induced brain dysfunction in the lab of Hari Sharma and Prasanta Kumar Dey under University Grants Commission and Indian Council of Medical Research Her main interest is now focused on Indian Medicinal drugs and their effects on the Central Nervous System Function, toxicology, neurorepair and neuroprotection. She is also investigating neurotoxicological profiles of many Ayurvedic traditional drugs with special reference to those containing metal oxide or metal ashes. Zhi-Qiang Zhang M.D. & Ph.D., Professor of Neurosurgery, is currently the director of department of Neurosurgery Guangdong Provincial of Chinese Medicine Hospital,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Professor Zhang has been engaged in clinical work, teaching and scientific research in neurosurgery for more than 30 years. He has extremely valuable experience on the treatment and research of brain tumors with integrated Chinese and Western medicine. Dr. Zhang is currently the deputy director of the China Branch of the International Society for Neurorestoration, the deputy director of the Department of Neurorestoration of the Chinese Medical Association, the chairman of the Department of Neurorestoration of the Guangdong Medical Association, the chairman of the Guangdong Provincial Neuro-oncology Committee of Integrative Chinese and Western Medicine. Dr. Zhang has published over 40 research papers, and presided over in a series of clinical and basic research projects and won provincial and municipal scientific research progress awards of China. Dr. Hari Shanker Sharma, Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) is currently working in Uppsala University Hospital, Department of Surgical Sciences, Division of Anesthesiology & Intensive Care Medicine, Uppsala University, Sweden. Dr Sharma obtained his Masters Degree from Bihar University with special expertise in Cell Biology in 1976 and was awarded the Gold Medal of Bihar University for securing 1st position in the 1st Class. Dr Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist, by training in the Department of Physiology, Institute of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D. in 1982 on “Blood-Brain Barrier in Stress.” After carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction (1982–1987), Dr Sharma joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government (1989–1991) to work on hyperthermia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (a living “Legend in Neuropathology in Europe”). Dr Sharma again joined Uppsala University and established a network of collaboration on “Experimental CNS Injury Research Group” as a lead investigator with eminent collaborators in various parts of Europe, USA, and Australia (1991–). On his work on hyperthermia Dr Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 and selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. On his meticulous works on the Blood Brain barrier and Brain edema (2000–2003) Dr. Sharma earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004. Currently his main research interest is Neuroprotection and Neuroregeneration, in relation to the Blood-brain barrier in stress, trauma, and drugs of abuse in health and disease. Dr. Sharma on his research on brain pathology and neuroprotection in different models received the prestigious award from The Laerdal Foundation of Acute Medicine, Stavanger, Norway, in 2005 followed by Distinguished International Scientists Collaboration Award by National Institute on Drug Abuse (NIDA), Baltimore, MD (2006–2008). His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP), and Awarded during their VI Annual Meeting in Lisbon, September 9–12, 2008. His recent research is aimed to find out the role of nanoparticles in Neurodegeneration and Neuroprotection using various treatment strategies that is supported by European Aerospace Research and Development (EOARD), London, UK and US Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Oh, USA. On his works on Blood–brain barrier in hypertension and diabetes together with Romanian colleagues, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania awarded Dr. Sharma with Honorary Doctorate of Medical Sciences in 2009. Dr Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan, November 2011. His works on Nanoneuroscience and development of nanomedicine to treat the CNS injuries has won accolades at various Government and International Scotties or Organization across the World. Accordingly Dr Sharma was decorated with the most prestigious ”Hind Rattan Award 2012” on the eve of Republic Day of India in January 2012 and Mahatma Gandhi Pravasi Gold Medal in October 2012 in House of Lords, London, UK. Dr Sharma was also invited to organize and chair Nanosymposium in Society for Neuroscience meetings in Chicago (2009), San Diego (2010), Washington DC (2011) and New Orleans (2012). Dr Sharma has published over 380 research papers, 75 reviews, 12 monographs, and 70 international book chapters and edited 15 book volumes.

Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
Hari Shanker Sharma, Dafin F. Muresanu, Rudy J. Castellani, Ala Nozari, José Vicente Lafuente, Z. Ryan Tian, Seaab Sahib, Igor Bryukhovetskiy, Andrey Bryukhovetskiy, Anca D. Buzoianu, Ranjana Patnaik, Lars Wiklund and Aruna Sharma

Personalized therapy and stem cell transplantation for pro-inflammatory modulation of cancer stem cells microenvironment in glioblastoma: Review
Igor Bryukhovetskiy, Oleg Pak, Yuri Khotimchenko, Andrey Bryukhovetskiy, Aruna Sharma and Hari Shanker Sharma

New advances on the inhibition of Siwei Xiaoliuyin combined with Temozolomide in glioma based on the regulatory mechanism of miRNA21/221
Zhiqiang Zhang, Yun Chen, Huijing Chen, Yanying Yang, Cong Li, Wengang Zhan, Qijia Tan, Caijun Xie, Hari Shanker Sharma and Aruna Sharma

Hydrogels based on modified pectins capable of modulating neural cell behavior as prospective biomaterials in glioblastoma treatment
Andrei Belousov, Sergei Titov, Nikita Shved, Grigorii Malykin, Valeri Kovalev, Irina Suprunova, Yuri Khotimchenko and Vadim Kumeiko

Fluorescein-guided surgery for spinal gliomas: Analysis of 220 consecutive cases
Zhenxing Sun, Linkai Jing, Yingwei Fan, Huifang Zhang, Lin Chen, Guihuai Wang, Hari Shanker Sharma and James Wang

Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix
Valeriy Shevchenko, Natalia Arnotskaya, Oleg Pak, Aruna Sharma, Hari Shanker Sharma, Yuri Khotimchenko, Andrey Bryukhovetskiy and Igor Bryukhovetskiy

Surgical treatment of low-grade brain tumors associated with epilepsy
Wei Zhang, Junxi Chen, Gang Hua, Dan Zhu, Qinghua Tan, Liming Zhang, Genbo Wang, Meichao Ding, Xiangshu Hu, Hua Li , Hari Shanker Sharma and Qiang Guo

Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma
Valeriy Shevchenko, Natalia Arnotskaya, Sergei Zaitsev, Aruna Sharma, Hari Shanker Sharma, Andrey Bryukhovetskiy, Oleg Pak, , Yuri Khotimchenko and Igor Bryukhovetskiy

Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient
Cong Li, Yinsheng Chen, Qingping Zhang, Chengcheng Guo, Furong Chen, Shaoyan Xi, Jing Zeng, Chao Ke, Hari Shanker Sharma and Zhongping Chen

Transforming growth factor-ß mimics the key proteome properties of CD133- differentiated and CD133+ cancer stem cells in glioblastoma
Igor Bryukhovetskiy, Valeriy Shevchenko, Natalia Arnotskaya, Tatyana Kushnir, Oleg Pak, Zgoda Victor, Sergey Zaitsev, Yuri Khotimchenko, Andrey Bryukhovetskiy, Aruna Sharma and Hari Shanker Sharma

Inhibitory effect of Siwei Xiaoliuyin on glioma angiogenesis in nude mice
Zhiqiang Zhang, Wengang Zhan, Huijing Chen, Yun Chen, Cong Li, Yanying Yang, Qijia Tan, Caijun Xie, Hari Shanker Sharma and Aruna Sharma

Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain
Sergei Zaitsev, Hari Shanker Sharma, Aruna Sharma, Igor Manzhulo, Alexander Polevshchikov, Igor Kudriavtsev, Yuri Khotimchenko, Oleg Pak, Andrey Bryukhovetskiy and Igor Bryukhovetskiy

Advanced multimodal imaging in differentiating glioma recurrence from post-radiotherapy changes
Cong Li, Yan-ling Gan, Huijing Chen, Yun Chen, Yuer Deng, Wengang Zhan, Qijia Tan, Caijun Xie, Hari Shanker Sharma and Zhiqiang Zhang

Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review
Irina Lyakhova, Mariia Piatkova, Valeriia Gulaia, Aleksandr Romanishin, Mikhail Shmelev, Andrey Bryukhovetskiy, Aruna Sharma, Hari Shanker Sharma, Rodion Khotimchenko and Igor Bryukhovetskiy

3-Bromofascaplysin is a prospective chemical compound for developing new chemotherapy agents in glioblastoma treatment


Irina Lyakhova, Mariia Piatkova, Yuri Khotimchenko, Maxim Zhidkov,Alexey Kantemirov, Rodion Khotimchenko, Andrey Bryukhovetskiy, Aruna Sharma, Hari Shanker Sharma and Igor Bryukhovetskiy